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ABN241

Sigma-Aldrich

Anti-GluR1 Antibody

from rabbit, purified by affinity chromatography

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Synonym(s):
Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse, rat

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GRIA1(2890)
mouse ... Gria1(14799)
rat ... Gria1(50592)

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This Item
MAB2263MABN71MABN832
Anti-GluR1 Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABN241

Anti-GluR1 Antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

purified antibody

clone

polyclonal

clone

RH95, monoclonal

clone

L21/32, monoclonal

clone

2D8, monoclonal

species reactivity

human, mouse, rat

species reactivity

rat

species reactivity

rat

species reactivity

human, rat

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

ELISA: suitable, immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

ELISA: suitable, electron microscopy: suitable, immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NP_113796

NCBI accession no.

NP_113796.1

NCBI accession no.

NP_000817

NCBI accession no.

NP_000817, NP_000818, NP_000819, NP_000820

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General description

Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling.

Specificity

This antibody recognizes the extracellular domain of GluR1.

Immunogen

KLH-conjugated linear peptide corresponding to the extracellular domain of rat GluR1.

Application

Anti-GluR1 Antibody is a highly specific rabbit polyclonal antibody, that targets GluR1 & has been tested in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GluR1 in human brain and human cerebellum tissue.

Quality

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected GluR1 in 10 µg of rat brain tissue lysate.

Target description

~110 kDa observed

Linkage

Replaces: PC246-100UG

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Tao Wu et al.
Journal of biomedical science, 26(1), 79-79 (2019-10-21)
Neuronal activity-induced changes in gene expression patterns are important mediators of neuronal plasticity. Many neuronal genes can be activated or inactivated in response to neuronal depolarization. Mechanisms that activate gene transcription are well established, but activity-dependent mechanisms that silence transcription
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Crosstalk between G-protein signaling and glutamatergic transmission within the brain reward circuits is critical for long-term emotional effects (depression and anxiety), cravings, and negative withdrawal symptoms associated with opioid addiction. A previous study showed that Regulator of G-protein signaling 4
Ayush Singh et al.
Journal of Alzheimer's disease : JAD, 78(4), 1661-1678 (2020-11-14)
Certain individuals, here referred to as Non-Demented with Alzheimer Neuropathology (NDAN), do not show overt neurodegeneration (N-) and remain cognitively intact despite the presence of plaques (A+) and tangles (T+) that would normally be consistent with fully symptomatic Alzheimer's disease
Dipen Rajgor et al.
Cell reports, 31(12), 107785-107785 (2020-06-25)
Molecular mechanisms underlying plasticity at brain inhibitory synapses remain poorly characterized. Increased postsynaptic clustering of GABAA receptors (GABAARs) rapidly strengthens inhibition during inhibitory long-term potentiation (iLTP). However, it is unclear how synaptic GABAAR clustering is maintained to sustain iLTP. Here
Shikha Snigdha et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(12), 3611-3622 (2016-03-26)
An increasing number of studies show that an altered epigenetic landscape may cause impairments in regulation of learning and memory-related genes within the aged hippocampus, eventually resulting in cognitive deficits in the aged brain. One such epigenetic repressive mark is

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