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MAB1598

Sigma-Aldrich

Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8

clone 7E3-1B8, Chemicon®, from mouse

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Synonym(s):
PSD-95
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

7E3-1B8, monoclonal

species reactivity

bovine, rat, mouse

species reactivity (predicted by homology)

human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

bovine ... Dlg4(100137840)
human ... DLG4(1742)
mouse ... Dlg4(13385)
rat ... Dlg4(29495)

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This Item
MABN1190ABN998CP35
Anti-PSD95 Antibody, clone 1A8.1 clone 1A8.1, from mouse

MABN1190

Anti-PSD95 Antibody, clone 1A8.1

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified antibody

species reactivity

bovine, rat, mouse

species reactivity

rat, human

species reactivity

human

species reactivity

rat

clone

7E3-1B8, monoclonal

clone

1A8.1, monoclonal

clone

polyclonal

clone

7E3-1B8, monoclonal

Gene Information

bovine ... Dlg4(100137840)
human ... DLG4(1742)
mouse ... Dlg4(13385)
rat ... Dlg4(29495)

Gene Information

human ... DLG4(1742)

Gene Information

human ... DLG4(1742)

Gene Information

rat ... Dlg4(29495)

shipped in

dry ice

shipped in

-

shipped in

wet ice

shipped in

wet ice

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General description

The postsynaptic density (PSD) is an electron dense structure just beneath the postsynaptic membrane. Several functions have been proposed for the PSD including regulating receptor number and clustering, anchoring signal transduction molecules at the synapse and mediating adhesion between the presynaptic and postsynaptic membranes. The most abundant PSD protein is the [alpha] subunit of the type II calcium/calmodulin dependent protein kinase ([alpha]CaMKII). This protein is likely to play a role in the calcium-mediated signal transduction at the synapse that mediates certain forms of synaptic plasticity. Another major PSD protein is PSD-95, a member of the guanylate kinase family (GUK) of proteins.

Specificity

Reacts with recombinant rat PSD-95 and identifies a band at approximately ~100 kDa, corresponding to PSD-95, on western blots of rat brain, mouse brain and bovine brain extracts. Also present in rat brain and mouse brain tissue extracts are bands of approximately 80 kDa and 50 kDa. PSD-95 is believed to initiate NMDA receptor clustering on the post synaptic membrane.

Immunogen

Recombinant rat PSD-95

Application

Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8 is an antibody against Post Synaptic Density Protein 95 for use in IC, IP & WB.
Immunocytochemistry:
A previous lot of this antibody was used in IC.

Immunoprecipitation:
A previous lot of this antibody was used in IP.

Optimal working dilutions must be determined by the end user.

Quality

Evaluated by Western Blot on Mouse brain lysates.

Western Blot Analysis:
1:500 dilution of this antibody detected PSD-95 on 10 µg of Mouse brain lysates.

Target description

~ 95 kDa

Linkage

Replaces: 04-1066

Physical form

Format: Purified
Purified mouse monoclonal IgG1 liquid in buffer containing PBS, pH 7.2, with 0.09% sodium azide and 50% glycerol.

Analysis Note

Control
Mouse brain, rat brain tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2


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PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
Zheng, S; Gray, EE; Chawla, G; Porse, BT; O'Dell, TJ; Black, DL
Nature Neuroscience null
Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease.
Lynch, G; Kramar, EA; Rex, CS; Jia, Y; Chappas, D; Gall, CM; Simmons, DA
The Journal of Neuroscience null
Noelle C Anastasio et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(2), 370-382 (2013-08-14)
Relapse vulnerability in cocaine dependence is rooted in genetic and environmental determinants, and propelled by both impulsivity and the responsivity to cocaine-linked cues ('cue reactivity'). The serotonin (5-hydroxytryptamine, 5-HT) 5-HT2C receptor (5-HT2CR) within the medial prefrontal cortex (mPFC) is uniquely
Francesca Puglisi et al.
PloS one, 8(6), e68063-e68063 (2013-07-11)
Torsin A (TA) is a ubiquitous protein belonging to the superfamily of proteins called "ATPases associated with a variety of cellular activities" (AAA(+) ATPase). To date, a great deal of attention has been focused on neuronal TA since its mutant
Activity-dependent local translation of matrix metalloproteinase-9.
Dziembowska, M; Milek, J; Janusz, A; Rejmak, E; Romanowska, E; Gorkiewicz, T; Tiron et al.
The Journal of Neuroscience null

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