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PP69

Sigma-Aldrich

β-Amyloid Peptide (1-42), Human

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Synonym(s):
β-Amyloid Peptide (1-42), Human, DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Empirical Formula (Hill Notation):
C203H312N56O59S
Molecular Weight:
4513.05

assay

≥95% (HPLC)

Quality Level

form

lyophilized

does not contain

preservative

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

50 mM Tris-HCl, pH >9.0: ≤1 mg/mL

shipped in

ambient

storage temp.

−20°C

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This Item
171596SCP0030AG968
Sigma-Aldrich

PP69

β-Amyloid Peptide (1-42), Human

Sigma-Aldrich

171596

β-Amyloid Peptide (1-42), Rat

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

form

lyophilized

form

lyophilized

form

lyophilized

form

powder

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

protect from light

storage condition

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

shipped in

ambient

shipped in

ambient

shipped in

-

shipped in

-

General description

Wild-type, human Aβ1-42 peptide. A number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimer’s Disease. Mutations in the genes encoding presenilin 1 and presenilin 2 have also been shown to alter the processing of βAPP, resulting in increased extracellular concentration of β-amyloid peptide Aβ1-42(43) relative to Aβ1-40. Biophysical and biochemical experiments suggest that Aβ1-42(43) may serve as a catalyst for the aggregation and deposition of β-amyloid peptide (Aβ) leading to neurotoxic effects associated with senile plaque formation. Furthermore, antibodies recog-nizing Aβ1-42 revealed that the long form of the peptide is increased in presenilin and βAPP mutants, while other studies have used Aβ specific antibodies to prevent the in vitro fibrillar aggregation of Aβ. Amino acid sequence verified by amino acid analysis or sequencing. This product is supplied in a form that is not neurotoxic prior to a preincubation step. The appearance of toxicity has recently been shown to correlate to the extent of β sheet structure. Useful for neurotoxicity studies and substrate cleavage assays.
Wild-type, human Aβ1-42 peptide. This product is supplied in a form that is not neurotoxic prior to a pre-incubation step. The level of toxicity has been shown to correlate to the extent of β sheet structure.

Immunogen

Human

Application

Substrate Cleavage Assays (30-100 μg/ml)

Warning

Toxicity: Standard Handling (A)

Sequence

H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Synthetic peptide corresponding to amino acid residues 1 - 42 of the processed human β-amyloid peptide.

Physical form

Supplied as a chloride salt.

Reconstitution

Reconstitute just prior to use. Do not store following reconstitution, as aggregation may occur.

Other Notes



Citron, M., et al. 1997. Nature Med.3, 67.
Hardy, J. 1997. Trends in Neurosci.20, 154.
Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA94, 4109.
Duff, K., et al. 1996. Nature 383, 710.
Iwatsubo, T., et al. 1994. Neuron13, 45.
Suzuki, N., et al. 1994. Science264, 133.
Simmons, L.K., et al. 1994. Mol. Pharmacol.45, 373.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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