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SCC034

Sigma-Aldrich

Human Mesenchymal Stem Cells (Bone Marrow)

Human mesenchymal stem cells derived from bone marrow that have a capacity for expansion in vitro while maintaining their potential for differentiation to multiple lineages including adipocytes, osteoblasts and chondrocytes.

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Synonym(s):
Human Bone Marrow MSCs, Human Bone Marrow Multipotent Stem Cells, Human MSCs
eCl@ss:
32011203
NACRES:
NA.75

biological source

human

Quality Level

technique(s)

cell culture | mammalian: suitable
cell culture | stem cell: suitable
cell differentiation: suitable

input

sample type mesenchymal stem cell(s)

shipped in

liquid nitrogen

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SCC038SCC036SCM130
technique(s)

cell culture | mammalian: suitable, cell culture | stem cell: suitable, cell differentiation: suitable

technique(s)

cell culture | mammalian: suitable, cell culture | stem cell: suitable, cell differentiation: suitable

technique(s)

cell culture | stem cell: suitable

technique(s)

cell culture | embryo: suitable, cell culture | stem cell: suitable

shipped in

liquid nitrogen

shipped in

dry ice

shipped in

liquid nitrogen

shipped in

dry ice

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

input

sample type mesenchymal stem cell(s)

input

sample type mesenchymal stem cell(s)

input

sample type mesenchymal stem cell(s)

input

-

General description

Mesenchymal stem cells, also known as marrow stromal cells, are defined as a self-renewing population of adherent, bone-marrow-derived multipotent progenitor cells with the capacity to differentiate into several mesenchymal cell lineages. In defined cultures in vitro, mesenchymal stem cells have been shown to readily differentiate into lineage-specific cells that form bone, cartilage, fat, tendon, and muscle tissues.

EMD Millipore’s Human Mesenchymal Stem Cells (Bone Marrow) are isolated from normal human bone marrow and are cryopreserved at P2 to ensure optimal phenotype and the highest viability and plating efficiency. These cells proliferate as an adherent cell monolayer and have shown a strong capacity for expansion in vitro while maintaining their potential for differentiation to multiple lineages including adipocytes, osteoblasts and chondrocytes..

Cell Line Description

Mesenchymal Stem Cells

Application

Research Category
Stem Cell Research

Components

1X106 viable Human Bone Marrow Mesenchymal Stem Cells

Quality

- Each vial contains at least 1X10⁶ viable cells at P2.
- Cell viability is greater than 75% at thaw and cells can be cultured for at least 3 population doublings after the initial thaw.
- Bone marrow donors tested negative for HIV, hepatitis B and hepatitis C.
- Apparently normal karyotype per cytogenetic analysis.
- Cells tested negative for mycoplasma contamination.

Storage and Stability

Human Mesenchymal Stem Cells (Bone Marrow) should be stored in liquid nitrogen. The cells are guaranteed for at least 3 population doublings without significantly affecting cell surface marker expression and differentiation potential.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Jung Eun Lee et al.
Polymers, 11(5) (2019-05-08)
Human mesenchymal stem cells (hMSCs) show enormous potential in regenerative medicine and tissue engineering. However, current use of hMSCs in clinics is still limited because there is no appropriate way to control their behavior in vivo, such as differentiation to
Sarah M Ridge et al.
Molecular cancer, 16(1), 31-31 (2017-02-06)
Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem
Niall J Logan et al.
Bone, 117, 149-160 (2018-09-17)
Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed
Iriczalli Cruz-Maya et al.
Polymers, 12(8) (2020-07-31)
Electrospinning is the leading technology to fabricate fibrous scaffolds that mimic the architecture of the extracellular matrix of natural tissues. In order to improve the biological response, a consolidated trend involves the blending of synthetic polymers with natural proteins to
Diego O Sanchez Ramirez et al.
Journal of functional biomaterials, 12(4) (2021-12-24)
The development of asymmetric membranes-i.e., matching two fibrous layers with selected composition and morphological properties to mimic both the epidermis and dermis-currently represents one of the most promising strategies to support skin regeneration during the wound healing process. Herein, a

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Protocols

Mesenchymal Stem Cell Culture Protocols

Information about mesenchyme, specifically mesenchymal stem cell procotols. Step-by-step cell culture protocols for mesenchymal stem cell (MSC) isolation, expansion and differentiation.

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