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SCC073

Sigma-Aldrich

UM-SCC-6 Squamous Carcinoma Cell Line

UM-SCC-6 is a unique head and neck squamous carcinoma cell line isolated from a tumor located at the base of the tongue of a male patient and is a suitable in vitro model of H&N carcinoma studies.

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Synonym(s):
UMSCC6

HNSCC

Head and neck squamous cell carcinoma cell line

H&N squamous cell carcinoma cell line
eCl@ss:
32011203
NACRES:
NA.75

biological source

human

Quality Level

technique(s)

cell culture | mammalian: suitable

shipped in

liquid nitrogen

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SCC074SCC070SCC076
biological source

human

biological source

human

biological source

human

biological source

human

shipped in

liquid nitrogen

shipped in

dry ice

shipped in

liquid nitrogen

shipped in

dry ice

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

All UM-SCC cell lines were derived in the lab of Dr. Thomas Carey at the University of Michigan and are exclusively distributed by Merck KGaA, Darmstadt, Germany. Access to UM-SCC cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.

THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@emdmillipore.com
UM-SCC-6 is a unique head and neck squamous carcinoma cell line isolated from a surgical resection of a tumor located at the base of the tongue of a male patient (1). The cell line is negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses.

UM-SCC-6 was established at the University of Michigan with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.

Reference:
1. Brenner, J.C., Graham, M.P., Kumar, B., Saunders, L.M., Kupfer, R., Lyons, R.H., Bradford, C.R., Carey, T.E. (2010) Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck 32(4):417-426.

Cell Line Description

Cancer Cells

Application

This product is available for sale to academic institutions or not-for-profit entities for research use. For information on commercial licensing please contact licensing@emdmillipore.com.

Quality

• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.

Storage and Stability

UM-SCC-6 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jose M Ayuso et al.
Nature communications, 14(1), 6681-6681 (2023-10-22)
Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous factors that dampen the immune response, including viruses like human immunodeficiency virus. In this study, we leverage

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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