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SCC070

Sigma-Aldrich

UM-SCC-1 Squamous Carcinoma Cell Line

UM-SCC-1 is a unique human head and neck squamous cell carcinoma (HNSCC) cell line isolated from a tumor located on the floor of the mouth of a male patient and is a suitable in vitro model of H&N carcinoma studies.

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Synonym(s):
University Michigan Squamous Cell Carcinoma, UMSCC1, H&N squamous cell carcinoma cell line, Head and neck squamous cell carcinoma cell line, HNSCC
eCl@ss:
32011203

biological source

human

Quality Level

technique(s)

cell culture | mammalian: suitable

shipped in

liquid nitrogen

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SCC072SCC073SCC077
technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

shipped in

liquid nitrogen

shipped in

liquid nitrogen

shipped in

liquid nitrogen

shipped in

liquid nitrogen

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

All UM-SCC cell lines were derived in the lab of Dr. Thomas Carey at the University of Michigan and are exclusively distributed by Merck KGaA, Darmstadt, Germany. Access to UM-SCC cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.

THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@emdmillipore.com

Head and neck squamous cell carcinoma (HNSCC) develops from the mucosal linings of the upper aerodigestive tract, comprising 1) the nasal cavity and paranasal sinuses, 2) the nasopharynx, 3) the hypopharynx, larynx, and trachea, and 4) the oral cavity and oropharynx. Squamous cell carcinoma (SCC) is the most frequent malignant tumor of the head and neck region. HNSCC is the sixth leading cancer by incidence worldwide. There are 500,000 new cases a year worldwide and two thirds occur in industrialized nations. It is caused by tobacco and alcohol consumption and infection with high-risk types of human papillomavirus (HPV). SCC often develops from preexisting dysplastic lesions. The five-year survival rate of patients with HNSCC is about 40-50%.

UM-SCC-1 is a unique head and neck squamous carcinoma cell line isolated from the tumor located on the floor of the mouth of a male patient. The cell line is negative for HPV-16 and for HLA-A2, a class I molecule of the major histocompatibility complex (MHC). The UM-SCC-1 cell line is 50% more invasive in vitro and displays a greater propensity for perineural and lymphatic invasion in vivo.

UM-SCC-1 was established at the University of Michigan (1) with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.

Reference:
1) Carey, T., et al. (2012) Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010 April; 32(4): 417–426.

Components

1) ≥1X106 viable UM-SCC-1 Squamous Carcinoma Cells: (Catalog No. SCC070). Store in liquid nitrogen.

Quality

• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negatrive for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.

Storage and Stability

UM-SCC-1 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Sung-Min Kang et al.
Anticancer research, 38(10), 5747-5757 (2018-10-03)
Few studies have examined the effect of 2'-hydroxycinnamaldehyde (HCA) on head and neck squamous cell carcinoma (HNSCC) cell invasion. This study examined the role of BMP7 on the anti-migration and anti-invasion activity of HCA using HNSCC cells. Matrigel invasion and
Jingyuan Li et al.
Cell death & disease, 11(5), 391-391 (2020-05-24)
Necroptosis is a recently discovered form of programmed cell death (PCD) having necrotic-like morphology. However, its presence and potential impact with respect to head and neck squamous cell carcinoma (HNSCC) are still unknown. The aim of this study was to
Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma.
Pearson, et al.
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-rhino-laryngologie et de Chirurgie Cervico-Faciale, 52, 41-41 (2023)
David P Molkentine et al.
Cancer research, 82(5), 916-928 (2021-12-31)
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensitive to radiotherapy via a ubiquitin-dependent signaling

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