MilliporeSigma
All Photos(2)

Documents

SCC180

Sigma-Aldrich

OECM-1 Human Oral Squamous Carcinoma Cell Line

OECM-1 human oral squamous carcinoma cell line is suitable for studies of cancer cell signaling, epithelial-mesenchymal transition (EMT), metastasis, invasion, and cancer cell stemness.

Sign Into View Organizational & Contract Pricing

Synonym(s):
OECM1, OEC-M1
eCl@ss:
32011203

biological source

human

technique(s)

cell culture | mammalian: suitable

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SCC070SCC469SCC193
technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

General description

Squamous cell carcinoma (SCC) is a common cancer type, developing in epithelial cells. Nearly all cancers of the oral cavity are squamous cell carcinomas, and the high recurrence rate among oral SCCs make these challenging targets for therapies. Established models of this cancer type continue to yield significant insights into the properties and potential treatments of head and neck cancers .
The OECM-1 human oral cavity squamous cell carcinoma cell line is a well-established model for squamous cell carcinoma. The OECM-1 cell line harbors a missense mutation in the p53 tumor suppressor , displays low EGFR expression , and is tumorigenic in nude mice . OECM-1 cells proliferate with a doubling time of 30-38 hours and are capable of anchorage-independent growth, forming spheroid colonies . OECM-1 cells have been intensively characterized in the literature for morphology, biomarker expression and drug response .
Source:
The OECM-1 human oral cavity squamous cell carcinoma cell line was derived from surgical resection of a primary tumor of a Taiwanese male patient .

Cell Line Description

Cancer Cells

Application

OECM-1 human oral squamous carcinoma cell line is suitable for studies of cancer cell signaling, epithelial-mesenchymal transition (EMT), metastasis, invasion, and cancer cell stemness.
Research Category
Cancer
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Quality

• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.

Storage and Stability

OECM-1 human oral cavity squamous carcinoma cell line should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Ching-Wen Chang et al.
Cell death & disease, 9(2), 194-194 (2018-02-09)
Cancer-initiating cells (CICs) are responsible for tumor initiation, progression, and therapeutic resistance; moreover, redox homeostasis is important in regulating cancer stemness. Previously, we have identified that cancer cells containing low intracellular reactive oxygen species levels (ROSLow cells) display enhanced features
Benoite Méry et al.
Oral oncology, 65, 51-56 (2017-01-23)
Head and neck cancer remains a significant public health concern. About 60% of patients die within 5years due to local recurrence. Head and neck squamous cell carcinoma (HNSCC) cell lines are important preclinical models in the search for new therapies
Shu-Chun Lin et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 33(2), 79-86 (2004-01-15)
Cell lines derived from oral squamous cell carcinoma (OSCC) exposed to variable etiological factors can bestow advantages in understanding the molecular and cellular alterations pertaining to environmental impacts. Most OSCC cell lines have been established from smoker patients or areca
C L Meng et al.
Archives of oral biology, 43(12), 979-986 (1999-01-07)
The objectives were to examine the production of eicosanoids in a Chinese human oral cancer cell line (OEC-M1) and to test the effects of interferon-gamma (IFN-gamma), eicosapentaenoic acid (EPA) and enzyme inhibitors on this biosynthesis. The eicosanoids were identified by
Guan-Cheng Huang et al.
Japanese journal of clinical oncology, 34(9), 499-504 (2004-10-07)
Platinum, 5-fluorouracil (5-FU) and taxanes are commonly used in chemotherapeutic modalities of various carcinomas. However, taxanes are rarely used in patients suffering from head and neck squamous cell carcinoma (HNSCC) in Taiwan. The purpose of this study was to assess

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service