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SCC074

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UM-SCC-17A Squamous Carcinoma Cell Line

UM-SCC-17A is a unique head and neck squamous carcinoma cell line isolated from the primary laryngeal carcinoma of a 48-year old female patient who failed to respond to radiation therapy and is a suitable in vitro model of H&N carcinoma studies.

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Synonym(s):
UMSCC17A

HNSCC

Head and neck squamous cell carcinoma cell line

H&N squamous cell carcinoma cell line
eCl@ss:
32011203
NACRES:
NA.75

biological source

human

Quality Level

technique(s)

cell culture | mammalian: suitable

shipped in

dry ice

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SCC075SCC076SCC073
technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

liquid nitrogen

General description

All UM-SCC cell lines were derived in the lab of Dr. Thomas Carey at the University of Michigan and are exclusively distributed by Merck KGaA, Darmstadt, Germany. Access to UM-SCC cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.

THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@emdmillipore.com
UM-SCC-17A is a unique head and neck squamous carcinoma cell line isolated from the primary laryngeal carcinoma of a 48-year old female patient who failed to respond to radiation therapy. The tumor persisted and metastasized to the neck, from where the UM-SCC-17B cell line was derived from. The patient achieved long-term remission after surgery . UM-SCC-17A is negative for HPV-16, HPV-18, Hepatitis A, B, C, HIV-1 & 2 viruses and grows as tightly packed colonies or islands.

UM-SCC-17A was established at the University of Michigan with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.

Cell Line Description

Endothelial Cells

Application

This product is available for sale to academic institutions or not-for-profit entities for research use. For information on commercial licensing please contact licensing@emdmillipore.com.

Quality

• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.

Storage and Stability

UM-SCC-17A cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2


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T E Carey et al.
Cancer research, 49(21), 6098-6107 (1989-11-01)
The squamous cell carcinoma (SCC) cell lines UM-SCC-17A and -17B were derived, respectively, from the primary laryngeal cancer and a metastatic neck tumor of a patient who failed to respond to radiation therapy but achieved long-term remission after surgery. The
J Chad Brenner et al.
Head & neck, 32(4), 417-426 (2009-09-18)
We established multiple University of Michigan Squamous Cell Carcinoma (UM-SCC) cell lines. With time, these have been distributed to other labs all over the world. Recent scientific discussions have noted the need to confirm the origin and identity of cell
Nunzia D'Onofrio et al.
Cancers, 12(9) (2020-09-04)
Betaines are food components widely distributed in plants, animals, microorganisms, and dietary sources. Among betaines, δ-valerobetaine (N,N,N-trimethyl-5-aminovaleric acid, δVB) shares a metabolic pathway common to γ-butyrobetaine (γBB). The biological properties of δVB are particularly attractive, as it possesses antioxidant, anti-inflammatory

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