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00170580

Ginsenoside Rb1

primary reference standard

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Synonym(s):
2-O-β-Glucopyranosyl-(3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl β-D-glucopyranoside, Arasaponin E1, Gynosaponin C, Gypenoside III, Notoginsenoside Rb1, Panaxoside Rb1, Sanchinoside E1, Sanchinoside Rb1
Empirical Formula (Hill Notation):
C54H92O23
CAS Number:
Molecular Weight:
1109.29
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

primary reference standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

SMILES string

C\C(C)=C\CC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]3CC[C@]4(C)[C@@H]3[C@H](O)C[C@@H]5[C@@]6(C)CC[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(C)(C)[C@@H]6CC[C@@]45C

InChI

1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/m0/s1

InChI key

GZYPWOGIYAIIPV-JBDTYSNRSA-N

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This Item
Y0001347PHL89208PHR2200
Ginsenoside Rb1 primary reference standard

00170580

Ginsenoside Rb1

Ginsenoside Rb1 European Pharmacopoeia (EP) Reference Standard

Y0001347

Ginsenoside Rb1

Ginsenoside Rb1 phyproof® Reference Substance

PHL89208

Ginsenoside Rb1

Ginsenoside Rg1 certified reference material, pharmaceutical secondary standard

Supelco

PHR2200

Ginsenoside Rg1

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

manufacturer/tradename

HWI

manufacturer/tradename

EDQM

manufacturer/tradename

PhytoLab

manufacturer/tradename

-

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

-

General description

Produced and qualified by HWI pharma services GmbH.
Exact content measured by quantitative NMR can be found on the certificate.

Ginsenoside Rb1 is one of the primary constituents of traditional Chinese medicine, Ginseng. It belongs to the group of triterpene saponins called ginsenosides and pharmacologically, it is one of the most active dammarane-type ginsenosides. It is known to have anti-tumor, anti-oxidant, anti-inflammatory, and cytoprotective properties.

Application

The primary reference standard can be used for identification, assay, and purity testing, method development, and validation.It can also be used as follows:
  • Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of ginsenoside Rb1, naringin, ginsenoside Rb2, and oridonin in rat plasma samples after administrating them weifuchun tablets
  • Multi-residue analysis of baicalin, baicalein, wogonoside, wogonin, scutellarin, berberine, coptisine, ginsenoside Rb1, and ginsenoside Re in biological samples of rat plasma by liquid chromatographic-tandem mass spectrometric (LC/MS/MS) method
  • Analysis of traditional Chinese herbal decoctions of Dushen Tang and Shenfu Tang for the quantification of 12 ginsenosides by UPLC-MS/MS technique
  • Analysis of rhizomes and roots of ginseng for the detection of 131 ginsenosides by UHPLC combined with a diode-array detector and quadrupole/time of flight tandem mass spectrometry (DAD-QTOF-MS/MS), along with the further determination of 19 ginsenosides by HPLC coupled with electrospray ionization-mass spectrometric detection

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Chiung-Hung Chang et al.
PloS one, 9(8), e105362-e105362 (2014-08-19)
Salmonella, a common zoonotic pathogen, causes gastroenteritis in both humans and animals. Traditional Chinese Medicine (TCM) has been used to improve gastrointestinal dysfunction and to modify the immune response to inflammation for centuries. This study used six herbal plants and

Articles

HPLC Separation of Ginsenosides from American Ginseng

The HPLC method for ginsenoside separation was optimized using a ginsenoside standard mixture and then applied to a sample of American Ginseng root. The experimental conditions and chromatograms are shown.

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