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N3915

Sigma-Aldrich

Notoginsenoside R1

≥98% (HPLC)

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Synonym(s):
(3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside, Sanchinoside R1
Empirical Formula (Hill Notation):
C47H80O18
CAS Number:
Molecular Weight:
933.13
MDL number:
PubChem Substance ID:
NACRES:
NA.25

biological source

Panax notoginseng (Burk.) F.H.Chen

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

C\C(C)=C\CC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2CC[C@]3(C)[C@@H]2[C@H](O)C[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5[C@H](C[C@@]34C)O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O

InChI

1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1

InChI key

LLPWNQMSUYAGQI-OOSPGMBYSA-N

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This Item
PHL89743SML3206SML0184
Notoginsenoside R1 ≥98% (HPLC)

Sigma-Aldrich

N3915

Notoginsenoside R1

Notoginsenoside R1 phyproof® Reference Substance

PHL89743

Notoginsenoside R1

Ginsenoside Rg5 ≥98% (HPLC)

Sigma-Aldrich

SML3206

Ginsenoside Rg5

Ginsenoside Rg3 ≥98% (HPLC)

Sigma-Aldrich

SML0184

Ginsenoside Rg3

assay

≥98% (HPLC)

assay

≥90.0% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

powder

color

white to off-white

color

-

color

white to beige

color

white to beige

solubility

H2O: 1 mg/mL, clear, colorless

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥5 mg/mL

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

-

application(s)

-

application(s)

-

Biochem/physiol Actions

Notoginsenoside R1 has been shown to exhibit antooxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory properties.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Shan Cong et al.
International immunopharmacology, 68, 137-144 (2019-01-10)
Pneumonia is a common lung disease in children with high fatality rate. Notoginsenoside R1 (NGR1) is the main active component extracted from the roots of Panax notoginseng (Burk.) F.H. Chen (Araliaceae). Here, we carefully explored the potential anti-inflammatory and protective
Kai Sun et al.
Life sciences, 81(6), 509-518 (2007-07-28)
Ginsenoside Rb1 (Rb1), ginsenoside Rg1 (Rg1), and notoginsenoside R1 (R1) are major active components of Panax notoginseng, a Chinese herb that is widely used in traditional Chinese medicine to enhance blood circulation and dissipate blood stasis. To evaluate the effect
Kouichi Yoshizaki et al.
Chemical & pharmaceutical bulletin, 60(3), 354-362 (2012-03-03)
Seven new dammarane-type triterpenoid saponins, chikusetsusaponin FK1 (1), chikusetsusaponin FK2 (2), chikusetsusaponin FK3 (3), chikusetsusaponin FK4 (4), chikusetsusaponin FK5 (5), chikusetsusaponin FK6 (6), and chikusetsusaponin FK7 (7), and eleven known triterpenoid saponins, ginsenoside Rb3 (9), ginsenoside Rc (10), chikusetsusaponin VI
Jian-Qing Ruan et al.
Journal of agricultural and food chemistry, 58(9), 5770-5776 (2010-04-22)
As a main and characteristic constituent in Radix notoginseng, the fate of notoginsenoside R1 (NGR1) in human is largely unknown. The present study investigated, for the first time, NGR1 metabolism by human intestinal bacteria and liver subcellular fractions, and permeability
T T X Dong et al.
Phytotherapy research : PTR, 19(8), 684-688 (2005-09-24)
The root of Panax notoginseng (Radix Notoginseng, Sanqi) is a commonly used traditional Chinese medicine, which is mainly cultivated in Wenshan of Yunnan China. The identified active constituents in Radix Notoginseng include saponin, ssavonoid and polysaccharide; however, the levels of

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