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142387

Sigma-Aldrich

2,4,6-Trimethylpyridine

ReagentPlus®, 99%

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Synonym(s):
2,4,6-Collidine, sym-Collidine
Empirical Formula (Hill Notation):
C8H11N
CAS Number:
108-75-8
Molecular Weight:
121.18
Beilstein:
107283
EC Number:
203-613-3
MDL number:
MFCD00006338
PubChem Substance ID:
57647138
NACRES:
NA.21

Quality Level

200

product line

ReagentPlus®

Assay

99%

form

liquid

refractive index

n20/D 1.498 (lit.)

bp

171-172 °C (lit.)

mp

−43 °C (lit.)

density

0.917 g/mL at 25 °C (lit.)

SMILES string

Cc1cc(C)nc(C)c1

InChI

1S/C8H11N/c1-6-4-7(2)9-8(3)5-6/h4-5H,1-3H3

InChI key

BWZVCCNYKMEVEX-UHFFFAOYSA-N

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1 of 4

This Item
27690258776W324426
2,4,6-Trimethylpyridine ReagentPlus®, 99%

Sigma-Aldrich

142387

2,4,6-Trimethylpyridine

2,4,6-Trimethylpyridine puriss. p.a., ≥99.0% (GC)

Sigma-Aldrich

27690

2,4,6-Trimethylpyridine

2,2,4-Trimethylpentane ReagentPlus®, ≥99%

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2,2,4-Trimethylpentane

2,3,5-Trimethylpyrazine natural, ≥95%, FG

Sigma-Aldrich

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2,3,5-Trimethylpyrazine

form

liquid

form

liquid

form

liquid

form

-

refractive index

n20/D 1.498 (lit.)

refractive index

n20/D 1.498 (lit.)

refractive index

n20/D 1.391 (lit.)

refractive index

n20/D 1.5040 (lit.)

bp

171-172 °C (lit.)

bp

171-172 °C (lit.)

bp

98-99 °C (lit.)

bp

171-172 °C (lit.)

mp

−43 °C (lit.)

mp

−43 °C (lit.)

mp

−107 °C (lit.)

mp

-

density

0.917 g/mL at 25 °C (lit.)

density

0.917 g/mL at 25 °C (lit.)

density

0.692 g/mL at 25 °C (lit.)

density

0.979 g/mL at 25 °C (lit.)

General description

2,4,6-Trimethylpyridine is a pyridine derivative. It has a pK of 7.4. The product can react with trifluoroiodomethane in cyclopentane solution to afford 1:1 complex. This complex was investigated by NMR (Nuclear Magnetic Resonance) spectroscopy. Collidine-buffered osmium tetroxide solutions have been prepared by adding osmium tetroxide solution to it. These solutions have been used as fixative for electron microscopic studies.
2,4,6-Trimethylpyridine can undergo oxidation with potassium permanganate to form 2,4,6-pyridinetricarboxylic acid.
Hindered base.

Application

2,4,6-Trimethylpyridine (collidine, s-collidine, 2,4,6-collidine) has been used in the preparation of a library of N-acyl aminocoumarins bearing low-molecular-weight N-acyl groups.
Useful solvent for the cleavage of hindered esters by anhydrous lithium iodide.
Tissue fixative for electron microscopy.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

FlameSkull and crossbones
GHS02,GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

131.0 °F - closed cup

Flash Point(C)

55 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Synthesis, structure, photoluminescence and magnetic properties of new 3-D lanthanide-pyridine-2, 4, 6-tricarboxylate frameworks
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CrystEngComm, 10(11), 1645-1652 (2008)
Stephen M Baumler et al.
Journal of electroanalytical chemistry (Lausanne, Switzerland), 812, 159-165 (2018-03-06)
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Substrate activity screening (SAS) is a fragment-based method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. The method consists of three steps: (i) a library of N-acyl aminocoumarins with diverse
Halogen complexes. III. The association of 2, 4, 6-trimethylpyridine and trifluoroiodomethane.
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Ab initio EOM-CCSD calculations have been performed on 3:1 FH:NH3 complexes at their own optimized MP2/6-31+G(d,p) geometries and at the optimized geometries in the hydrogen-bonding regions of corresponding 3:1 FH:collidine complexes. The isolated gas-phase equilibrium 3:1 FH:NH3 complex has an
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