32492
Florfenicol amine
VETRANAL®, analytical standard
Synonym(s):
(αR)-α-[(1S)-1-Amino-2-fluoroethyl]-4-(methylsulfonyl)benzenemethanol, D-(−)-threo-2-Amino-3-fluoro-1-[4-(methylsulfonyl)phenyl]-1-propanol
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About This Item
Empirical Formula (Hill Notation):
C10H14FNO3S
CAS Number:
Molecular Weight:
247.29
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C10H14FNO3S/c1-16(14,15)8-4-2-7(3-5-8)10(13)9(12)6-11/h2-5,9-10,13H,6,12H2,1H3/t9-,10-/m1/s1
SMILES string
CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@H](N)CF
InChI key
XLSYLQDVLAXIKK-NXEZZACHSA-N
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Related Categories
General description
Florfenicol amine is a polar metabolite of florfenicol.
Application
Florfenicol amine may be used as an analytical reference standard for the determination of the analyte in:
- Poultry and porcine muscle and liver by gas chromatography-negative chemical ionization mass spectrometry (GC-NCI/MS) with selected ion monitoring (SIM) detection.
- Food samples by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) operating in selected reaction monitoring (SRM) detection mode.
- Chicken muscle by LC-ESI-MS/MS with multiple reaction monitoring (MRM) detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Jianzhong Shen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(14-15), 1523-1529 (2009-04-28)
A sensitive and reliable method using gas chromatography-negative chemical ionization mass spectrometry (GC-NCI/MS) was developed for the simultaneous determination of chloramphenicol (CAP), thiamphenicol (TAP), florfenicol (FF), and florfenicol amine (FFA) at trace levels in muscle and liver. Before extraction with
Christopher L Wrzesinski et al.
Journal of AOAC International, 86(3), 515-520 (2003-07-11)
A method for quantifying florfenicol amine (FFA) in channel catfish muscle was validated according to U.S. Food and Drug Administration guidelines. FFA is the proposed marker residue for the veterinary antibiotic florfenicol in catfish muscle for regulatory surveillance purposes. The
Byung-Kwon Park et al.
Research in veterinary science, 84(1), 85-89 (2007-06-16)
A study on the bioavailability and pharmacokinetics of florfenicol was conducted in six healthy dogs following a single intravenous (i.v.) or oral (p.o.) dose of 20 mg kg(-1) body weight (b.w.). Florfenicol concentrations in serum were determined by a high-performance
Jiancheng Li et al.
Journal of agricultural and food chemistry, 54(25), 9614-9619 (2006-12-07)
A study of the tissue depletion of florfenicol (FF) administered intramuscularly twice to swine at a dose rate of 20 mg per kg of body weight at 24 h intervals was carried out. Forty healthy cross swine were treated with
A P Pfenning et al.
Journal of AOAC International, 83(1), 26-30 (2000-02-29)
A gas chromatographic (GC) method is presented for determining residues of chloramphenicol (CAP), florfenicol (FF), florfenicol amine (FFa), and thiamphenicol (TAP) in shrimp tissues, with meta-nitrochloramphenicol (mCAP) as the internal standard. The composited shrimp is extracted with basic ethyl acetate
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