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89067

Supelco

Corosolic acid

analytical standard

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Synonym(s):
(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid, 2α-Hydroxyursolic acid, Colosolic acid, Corsolic acid, Glucosol
Empirical Formula (Hill Notation):
C30H48O4
CAS Number:
Molecular Weight:
472.70
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥85.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

SMILES string

O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1

InChI

1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1

InChI key

HFGSQOYIOKBQOW-ZSDYHTTISA-N

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This Item
G0549PHL800651148737
vibrant-m

89067

Corosolic acid

vibrant-m

PHL80065

Corosolic acid

vibrant-m

1148737

Corosolic acid

grade

analytical standard

grade

-

grade

primary reference standard

grade

pharmaceutical primary standard

assay

≥85.0% (HPLC)

assay

≥98% (HPLC)

assay

≥90.0% (HPLC)

assay

-

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

food and beverages

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

food and beverages

application(s)

pharmaceutical (small molecule)

Application

Corosolic acid may be used as a reference standard in the determination of corosolic acid in Eriobotrya japonica leaves using reversed-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Triterpene phytochemical found in medicinal herbal extracts. Possesses antiatherosclerotic, antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral and antineoplastic activities.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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25G
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Sigma-Aldrich

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Determination of corosolic acid in Eriobotrya japonica leaves by reversed-phase high performance liquid chromatography.
CH, et al.
Se Pu / Chinese Journal of Chromatography, 24(5), 492-494 (2006)
Sidney J Stohs et al.
Phytotherapy research : PTR, 26(3), 317-324 (2011-11-19)
Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This review summarizes the current literature regarding banaba and its constituents. The hypoglycemic
Ke Wang et al.
Oncology reports, 39(6), 2777-2786 (2018-04-06)
Retinoblastoma (Rb) is the most frequent primary intraocular tumor usually diagnosed in infants and children, and current therapy for such disease is still limited. Corosolic acid (CA), an ursane-type pentacyclic triterpene, has been assessed as a promising anticancer agent with little impact
Ganapathy Sivakumar et al.
Biotechnology journal, 4(12), 1704-1711 (2009-12-01)
Diabetes is one of the nation's most prevalent, debilitating and costly diseases. For diabetes, frequent insulin treatment is very expensive and may increase anti-insulin antibody production, which may cause unwanted side effects. Corosolic acid may also have some efficacy in
Baohong Li et al.
Pakistan journal of pharmaceutical sciences, 27(3), 511-516 (2014-05-09)
A sensitive and robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of corosolic acid (CRA) in rat plasma. The plasma samples were prepared by a simple protein precipitation treatment. Chromatographic separation was performed on

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