920193

Cyrene^™ 2-Methyltetrahydrofuran Blend

BioRenewable, DMF and NMP Substitute

• Synonym(s): 2-MeTHF Solution, 2-Methyltetrahydrofuran solution, Cyrene solution
• Empirical Formula (Hill Notation): C₆H₈O₃
• Molecular Weight: 128.13
• UNSPSC Code: 12352212
• NACRES: NA.07

Properties

• form: liquid
• contains: 30-80 ppm BHT as stabilizer
• greener alternative product characteristics: Safer Solvents and Auxiliaries; Use of Renewable Feedstocks; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• renewable carbon content: 100%
• density: 1.153 g/mL
• greener alternative category: , Aligned

Description

General description

Cyrene^™ 2-Methyltetrahydrofuran Blend with BHT as an inhibitor is specially formulated for use in automated processes and applications where lower viscosity is required, making it easier to handle while maintaining high yields.

This Cyrene^™ blend is an alternative for NMP and DMF in many cross-coupling reactions. Neither Cyrene^™ nor 2-Methyltetrahydrofuran have any genotoxic or mutagenic concerns associated with their use, making them much safer alternatives to traditional aprotic solvents.

This new blend is part of our Biorenewable product line, meaning that it is made from renewable resources and does not compete with food resources for its production, making it more environmentally sustainable for the future. The material has also been independently certified as 100% renewable carbon.

We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is BioRenewable and thus aligns with "Safer Solvents and Auxiliaries" and "Use of Renewable Feedstocks". Click here for more information.

Application

This cosolvent solution has been shown to have similar reaction yields to NMP and DMF for many cross-coupling reactions, such as:

• HATU Amide Coupling - Replacement for DMF in amide and dipeptide coupling reactions
• Suzuki-Miyaura coupling reaction.
• Sonogashira coupling reaction.
• Reductive homocoupling reaction.

Features and Benefits

• Independently certified as 100% renewable carbon.
• Closer physical properties of NMP and DMF while maintaining high reaction yields.
• Sustainably produced and environmentally less hazardous than more traditional petroleum aprotic solvents
• Both Cyrene and 2-MeTHF are also much safer for handling without the genotoxic concerns of other solvents.
• It has a lower viscosity than neat Cyrene making it more optimized for automated processes.

Other Notes

To see other BioRenewable or Greener Solvents

Legal Information

CYRENE is a trademark of Circa Group Pvt Ltd

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H225,H315,H318
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2
• supp_hazards: EUH019
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2