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Collagenase Type IV, Cls IV

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Collagen A, Type IV Gelatinase



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storage temp.


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100, 500

General description

Collagenase Type IV, Cls IV is a member of the mammalian extracellular neutral metalloproteinases family. It digests type IV collagen, which is a major structural constituent of the basement membrane.
This product is identical to Biochrom GmbH part numbers C4-22 and C4-28. Enzyme blending from collagenase, clostripain, with tryptic and proteolytic activities. Recommended for the isolation of Islets of Langerhans. Specific activity is 125 to 250 Mandl units per milligram of powdered substance.


Collagenase Type IV, Cls IV may be used:
  • as a component in Dulbecco′s modified Eagle′s medium (DMEM)/F12 to digest endometrial samples isolated from in vitro fertilization (IVF) patients
  • for collagenase perfusion to isolate hepatocytes using collagenase-liver perfusion method in rats
  • in the isolation of rat glomerular endothelial cells (GEndCs)

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Sina M Schalbetter et al.
Science advances, 8(9), eabi6672-eabi6672 (2022-03-03)
The prefrontal cortex (PFC) is a cortical brain region that regulates various cognitive functions. One distinctive feature of the PFC is its protracted adolescent maturation, which is necessary for acquiring mature cognitive abilities in adulthood. Here, we show that microglia
Liquan Jin et al.
Molecular medicine reports, 27(3) (2023-02-18)
The present study aimed to identify the function and expression of trimethylated protein histone H3 lysine 36 (H3K36)me3 and the upstream specific enzyme histone methyltransferase SET domain containing 2 (SETD2), during the differentiation of hepatic oval cells (HOCs) into cholangiocytes
Yulia Gnainsky et al.
Fertility and sterility, 94(6), 2030-2036 (2010-03-27)
To study whether an injury-induced inflammation might be the mechanism underlying the favorable effect of endometrial biopsy on the implantation rate in in vitro fertilization (IVF) patients. Controlled clinical study. A medical center IVF unit and a research institute. Women
Mingtai Gui et al.
Experimental and therapeutic medicine, 22(6), 1446-1446 (2021-11-02)
Continuous and irreversible cardiac hypertrophy can induce cardiac maladaptation and cardiac remodeling, resulting in increased risk of developing cardiovascular diseases. The present study was conducted to investigate the therapeutic effect of Huoxue Qianyang Qutan recipe (HQQR) on angiotensin II (Ang
Weixing Dai et al.
Cancer communications (London, England), 42(9), 848-867 (2022-07-30)
Abnormal expression of protein tyrosine phosphatases (PTPs) has been reported to be a crucial cause of cancer. As a member of PTPs, protein tyrosine phosphatase receptor type O (PTPRO) has been revealed to play tumor suppressive roles in several cancers

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