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E1644

Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt dihydrate

BioUltra, 98.5-101.5%

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Synonym(s):
Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2
Empirical Formula (Hill Notation):
C10H14N2Na2O8 · 2H2O
CAS Number:
Molecular Weight:
372.24
Beilstein:
3900609
EC Number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

product line

BioUltra

Assay

98.5-101.5%

form

powder

reaction suitability

reagent type: chelator

impurities

≤0.005% Phosphorus (P)
≤0.05% NH3
≤0.1% Insoluble matter

pH

4.0-6.0 (0.1 M in H2O)

mp

248 °C (dec.) (lit.)

solubility

H2O: 0.1 M, clear, colorless

cation traces

Al: ≤0.001%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
Pb: ≤0.001%
Zn: ≤0.0005%

storage temp.

room temp

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

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This Item
ED2SSE6635E5134
assay

98.5-101.5%

assay

98.5-101.5% (titration)

assay

98.5-101.5%

assay

99.0-101.0% (titration)

form

powder

form

powder

form

powder

form

powder

impurities

≤0.005% Phosphorus (P), ≤0.05% NH3, ≤0.1% Insoluble matter

impurities

-

impurities

-

impurities

≤0.005% Insolubles, ≤0.1% Nitrilotriacetic acid (NTA)

pH

4.0-6.0 (0.1 M in H2O)

pH

-

pH

-

pH

-

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

General description

Ethylenediaminetetraacetic acid (EDTA) is a substituted diamine and a chelator of metal ions. It has anticoagulant and antibacterial activity. EDTA is an inhibitor of metalloprotease. It evades the undesirable effects of ferric, cupric and manganic ions in bleaching. It blocks cellular division, chlorophyll synthesis and algal biomass production.

Application

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - STOT RE 2 Inhalation

Target Organs

Respiratory Tract

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Modulation of matrix metalloproteinase activity by EDTA prevents posterior capsular opacification
Hazra S, et al.
Molecular Vision, 18, 1701-1701 (2012)
Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction (2013)
EDTA: the chelating agent under environmental scrutiny
Oviedo C and Rodriguez J
Quimica nova, 26(6), 901-905 (2003)
Matthew R Miller et al.
Journal of biological methods, 2(3), e23-e23 (2015-10-13)
Over the past two decades, researchers have struggled to efficiently express foreign DNA in primary macrophages, impeding research progress. The applications of lipofection, electroporation, microinjection, and viral-mediated transfer typically result in disruptions in macrophage differentiation and function, low expression levels
Meritxell Espino Guarch et al.
eLife, 7 (2018-01-23)
Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we demonstrated

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