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PHR1071

Supelco

Citric acid, Anhydrous

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Citric acid
Linear Formula:
HOC(COOH)(CH2COOH)2
CAS Number:
Molecular Weight:
192.12
Beilstein/REAXYS Number:
782061
EC Number:
MDL number:
eCl@ss:
39021801
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. A1202000
traceable to USP 1134368

API family

citric acid

CofA

current certificate can be downloaded

expl. lim.

8 %, 65 °F

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

mp

153-159 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

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1 of 4

This Item
CX172394676251275
Citric acid, Anhydrous Pharmaceutical Secondary Standard; Certified Reference Material

PHR1071

Citric acid, Anhydrous

Citric Acid, Anhydrous anhydrous Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS

CX1723

Citric Acid, Anhydrous

Citric acid certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

94676

Citric acid

Citric acid ACS reagent, ≥99.5%

251275

Citric acid

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

-

format

neat

format

-

format

neat

format

-

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

200

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

certified reference material, TraceCERT®

grade

ACS reagent

storage temp.

2-30°C

storage temp.

room temp

storage temp.

-

storage temp.

-

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Citric acid is a common ingredient in pharmaceutical formulations. It finds use in antacids and dentrifices because of the effervescent effect it generates upon combination with carbonates or bicarbonates. Citric acid may also be used as a buffering agent and it assists in the dispersion of suspensions in order to ensure the stability of the active ingredients and enhance the efficacy of antioxidants.

Application

Anhydrous citric acid may be used as a reference standard in determining the concentration of citric acid present in biological fluids using spectrophotometric method.
Citric acid, Anhydrous may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and milk samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7603 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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A simplified photometric method for the determination of citric acid in biological fluids
Ettinger.HR, et al.
The Journal of Biological Chemistry, 199(2), 531-536 (1952)
Development and validation of an assay for citric acid/citrate and phosphate in pharmaceutical dosage forms using ion chromatography with suppressed conductivity detection
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