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PHR1123

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Isopropyl myristate

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Isopropyl tetradecanoate, Myristic acid isopropyl ester
Linear Formula:
CH3(CH2)12COOCH(CH3)2
CAS Number:
Molecular Weight:
270.45
Beilstein/REAXYS Number:
1781127
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. I0750000
traceable to USP 1350400

API family

isopropyl myristate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.434 (lit.)

bp

193 °C/20 mmHg (lit.)

mp

~3 °C (lit.)

density

0.85 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCCCC(=O)OC(C)C

InChI

1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3

InChI key

AXISYYRBXTVTFY-UHFFFAOYSA-N

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This Item
W355690M07571350400
Isopropyl myristate Pharmaceutical Secondary Standard; Certified Reference Material

PHR1123

Isopropyl myristate

Isopropyl myristate ≥98%

W355690

Isopropyl myristate

Isopropyl myristate ≥90% (GC)

M0757

Isopropyl myristate

Isopropyl myristate United States Pharmacopeia (USP) Reference Standard

1350400

Isopropyl myristate

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

application(s)

flavors and fragrances

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

-

format

-

format

neat

Quality Level

300

Quality Level

400

Quality Level

-

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

Fragrance grade, Halal, Kosher

grade

-

grade

pharmaceutical primary standard

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

General description

Isopropyl myristate is an ester of isopropyl alcohol myristic acid. It is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It also finds applications as a flavoring agent in the food industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7001 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

10 - Combustible liquids

wgk_germany

awg

flash_point_f

302.0 °F

flash_point_c

> 150 °C


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CRC Handbook of Food, Drug, and Cosmetic Excipients (1992)
Vinécius Raphael de Almeida Borges et al.
International journal of nanomedicine, 8, 535-544 (2013-02-16)
Topical administration of dapsone can be an alternative route for treatment of leprosy and can also provide new therapeutic applications for an established drug. However, the physicochemical properties of dapsone make it difficult to incorporate into conventional formulations. The current
Fahima M Hashem et al.
AAPS PharmSciTech, 12(3), 879-886 (2011-07-05)
The objective of the present study was to formulate and evaluate microemulsion systems for topical delivery of clotrimazole (CTM). The solubility of CTM in various oils was determined to select the oil phase of the microemulsion systems. Pseudoternary phase diagrams
Ji Zhang et al.
International journal of pharmaceutics, 421(1), 34-44 (2011-10-01)
In this study, microemulsion microstructures, key formulation variables, and their relationship to drug transdermal permeation enhancement were investigated. A microemulsion system with high water soluble capacity was developed, using isopropyl myristate, Labrasol, and Cremophor EL as oil, surfactant, and co-surfactant
Qian Zhang et al.
Pharmaceutical research, 30(1), 32-40 (2012-08-28)
In principle, maximum transepidermal fluxes of solutes should be similar for different vehicles, except when the solute or vehicle modifies the skin. Here we estimated maximum flux, stratum corneum solubility, diffusivity and permeability coefficient for a range of similarly sized

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