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S6387

Sigma-Aldrich

Sulfadiazine sodium salt

≥98% (HPLC)

Synonym(s):

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide sodium salt, SPS Agar Supplement

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About This Item

Empirical Formula (Hill Notation):
C10H9N4NaO2S
CAS Number:
Molecular Weight:
272.26
Beilstein/REAXYS Number:
4068213
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥98% (HPLC)

form

crystalline powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

SMILES string

Nc1ccc(cc1)S(=O)(=O)N([Na])c2ncccn2

InChI

1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1

InChI key

JLDCNMJPBBKAHH-UHFFFAOYSA-N

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General description

Sulfadiazine sodium salt is a broad-spectrum antibiotic belonging to the class of sulfonamides commonly used against gram-postive and gram-negative microorganisms in humans and veterinary medication. Its mode of action involves inhibiting the multiplication of bacteria as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfadiazine may be used as an internal standard for the determination of sulfapyridine in biological samples using high-performance liquid chromatography technique.

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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High-performance liquid chromatographic method for determination of sulfapyridine in human saliva using post-column, in-line derivatization with fluorescamine
Sista.S.H, et al.
Journal of Chromatography. B, Biomedical Applications, 273(2), 103-106 (1983)
Drugs: Synonyms and Properties (2017)
Jia-Hui Cheng et al.
International immunopharmacology, 82, 106302-106302 (2020-02-23)
Toxoplasma gondii (T. gondii) is a known neurotropic protozoan that remains in the central nervous system and induces neuropsychiatric diseases in intermediate hosts. Arctigenin (AG) is one of the major bioactive lignans of the fruit Arctium lappa L. and has
Yu-Nan Lu et al.
International immunopharmacology, 84, 106539-106539 (2020-05-04)
Toxoplasmosis is a parasitic zoonosis with the highest incidence in humans. Severe lesions due to acute toxoplasmosis have been recorded in the visceral organs including the liver, where hepatocytes and Kupffer cells are important innate immune cells. Arctigenin (AG) is
Chun-Xue Zhou et al.
Antimicrobial agents and chemotherapy, 63(10) (2019-08-07)
In this study, we analyzed the global metabolomic changes associated with Toxoplasma gondii infection in mice in the presence or absence of sulfadiazine sodium (SDZ) treatment. BALB/c mice were infected with T. gondii GT1 strain and treated orally with SDZ

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