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TWEEN® 40, Polyoxyethylenesorbitan monopalmitate
CAS Number:
MDL number:



Quality Level


~90.0% (GC)


viscous liquid

mol wt

estimated mol wt 1277


Palmitic acid, ~90.0% (balance primarily stearic acid)

greener alternative product characteristics

Use of Renewable Feedstocks
Design for Degradation
Learn more about the Principles of Green Chemistry.


0.027 (20-25°C)



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Inchi Key


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General description

ECO Tween® 40, also known as Polyoxyethylenesorbitan monopalmitate, is a bio-based, nonionic detergent manufactured from natural fatty acid (palmitic acid). This surfactant, derived from natural sources, provides various functional advantages, such as detergency, emulsification, and wetting. Its versatility makes it well-suited for a variety of applications in biochemical and biological research, with common uses including cell lysis, nuclei isolation and cell fractionation.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is a biobased surfactant and is aligned with the 7th principle of Green Chemistry "Use of Renewable Feedstocks" and the 10th principle "Design for Degradation".


Non-ionic detergent used for cell lysis, nuclei isolation and cell fractionation.
Polyoxyethylenesorbitan monopalmitate, or Tween® 40, has been used in a study to assess the determination of iodide in urine based on a chemiluminescence system. It has also been used in a study to investigate the delivery of astaxanthin and canthaxanthin to HepG2 cells.

Features and Benefits

  • 100 % Renewable
  • 100 % Bio-based
  • Certified to the USDA BioPreferred Program
  • Lower carbon footprint than petrochemical-based versions
  • High-purity chemical suitable for a wide variety of research applications

Legal Information

ECO TWEEN is a registered trademark of Croda Inc.
TWEEN is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids



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Determination of iodide in urine based on chemiluminescence system of cerium (IV)-tween 40-iodide
Li and Xie
Journal of Luminescence, 132, 5-5 (2012)
Christine Boesch-Saadatmandi et al.
Cytotechnology, 63(1), 89-97 (2010-12-15)
The present investigation aimed to compare fetal calf serum (FCS) and Tween 40 with the commonly employed tetrahydrofuran (THF) with respect to cytotoxicity, stability of the solubilized carotenoids, and uptake and accumulation of the xanthophylls astaxanthin (AX) and canthaxanthin (CX)
J G Culvenor et al.
Journal of cellular biochemistry, 20(2), 127-138 (1982-01-01)
Plasma membrane was isolated from the mouse T lymphoma cell line WEHI-22 using four different methods of cell disruption followed by centrifugal fractionation. Disruption by nitrogen cavitation or by shearing with a cell pump produced plasma membrane vesicles of similar
Takashi Sugita et al.
Journal of clinical microbiology, 41(10), 4695-4699 (2003-10-09)
Lipophilic yeasts of the genus Malassezia are part of the normal cutaneous microflora and are considered one of the factors that trigger atopic dermatitis (AD). We isolated two strains of Malassezia from a healthy Japanese female. Analysis of the D1/D2
Lu-Min Vaario et al.
Mycorrhiza, 12(1), 1-5 (2002-04-24)
Saprotrophic growth of Tricholoma matsutake isolates was investigated over Pinus densiflora bark fragments either on soil or on agar media. Preferential colonization of pine bark fragments by hyphae, in glucose-deprived environments suggested that Matsutake was able to extract some nutrients

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