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T1600000

α-Tocopherol acetate

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
DL-α-Tocopherol acetate, Vitamin E acetate, all-rac-α-Tocopheryl acetate
Empirical Formula (Hill Notation):
C31H52O3
CAS Number:
Molecular Weight:
472.74
Beilstein/REAXYS Number:
97512
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

tocopherol

form

liquid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

density

0.96 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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This Item
1667701Y000038429992
α-Tocopherol acetate European Pharmacopoeia (EP) Reference Standard

T1600000

α-Tocopherol acetate

Alpha Tocopheryl Acetate United States Pharmacopeia (USP) Reference Standard

1667701

Alpha Tocopheryl Acetate

DL-α-Tocopherol acetate tested according to Ph. Eur.

29992

DL-α-Tocopherol acetate

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

-

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

-

format

neat

format

neat

format

neat

format

-

form

liquid

form

-

form

solid

form

liquid

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. α-Tocopherol acetate, a supplement of α-tocopherol, is an active form of vitamin E. This lipid-soluble antioxidant is found in whole grains, nuts, and oils. It is known to scavenge reactive oxygen species by interacting with lipids during oxidative stress.

Application

α-Tocopherol acetate may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

No data available

flash_point_c

No data available


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Alpha Tocopherol United States Pharmacopeia (USP) Reference Standard

USP

1667600

Alpha Tocopherol

all-rac-α-Tocopheryl acetate (Vitamin E acetate), EMPROVE® ESSENTIAL, Ph. Eur., BP, USP, FCC

SAFC

5.00952

all-rac-α-Tocopheryl acetate

Dexpanthenol European Pharmacopoeia (EP) Reference Standard

D0730000

Dexpanthenol

Alpha Tocopherol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1031

Alpha Tocopherol

Vitamin E dry powder, (50 g all-rac-a-tocopheryl acetate in 100 g subst), EMPROVE® ESSENTIAL, Ph. Eur., BP, USP

SAFC

5.00859

Vitamin E

(±)-α-Tocopherol analytical standard

Supelco

47783

(±)-α-Tocopherol

all-rac-α-Tocopherol EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 307

SAFC

5.00949

all-rac-α-Tocopherol

RRR-?-Tocopheryl acetate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3804-3805 (2013)
ANTIOXIDANTS-Role of Antioxidant Nutrients in Defense Systems
Encyclopedia of food sciences and nutrition, 282-289 (2003)
Determination of eight water-and fat-soluble vitamins in multi-vitamin pharmaceutical formulations by high-performance liquid chromatography
Moreno P and Salvado V
Journal of Chromatography A, 870(1-2), 207-215 (2000)
Flow injection spectrophotometric determination of vitamin E in pharmaceuticals, milk powder and blood serum using potassium ferricyanide-Fe (III) detection system
Jadoon S, et al.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 21(6), 712-715 (2010)
Po-Hsien Huang et al.
Science signaling, 6(267), ra19-ra19 (2013-03-21)
Vitamin E is a fat-soluble vitamin with antioxidant properties. Tocopherols are the predominant form of vitamin E found in the diet and in supplements and have garnered interest for their potential cancer therapeutic and preventive effects, such as the dephosphorylation

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