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T9159

Sigma-Aldrich

Trichloroacetic acid

BioXtra, ≥99.0%

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Synonym(s):
TCA
Linear Formula:
Cl3CCOOH
CAS Number:
Molecular Weight:
163.39
Beilstein/REAXYS Number:
970119
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NB.22

vapor density

<1 (vs air)

Quality Level

vapor pressure

1 mmHg ( 51 °C)

product line

BioXtra

assay

≥99.0%

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.03%

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

1.62 g/mL at 25 °C (lit.)

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.01%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

storage temp.

2-8°C

SMILES string

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

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1 of 4

This Item
T4885T639991230
vibrant-m

T9159

Trichloroacetic acid

Premium Grade
vibrant-m

T4885

Trichloroacetic acid

-
vibrant-m

T6399

Trichloroacetic acid

-
vibrant-m

91230

Trichloroacetic acid

-
assay

≥99.0%

assay

≥99.0% (titration)

assay

≥99.0%

assay

≥99.5% (T)

bp

196 °C (lit.)

bp

196 °C (lit.)

bp

196 °C (lit.)

bp

196 °C (lit.)

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

impurities

-

impurities

Substances darkened by sulfuric acid, passes test, ≤0.01% insoluble matter

impurities

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

H2O: 0.5 M at 20 °C, clear, colorless

solubility

H2O: 1 g/10 mL

solubility

H2O: 1 g/10 mL

solubility

water: soluble 81.7 g/L at 20 °C

General description

Trichloroacetic acid (TCA) is an important metabolic product of trichloroethylene (TCE) metabolism.

Application

Trichloroacetic acid has been used:
  • for protein precipitation
  • as a component in the extract solution used for the measurement of malondialdehyde and glutathione
  • to precipitate the transfected and treated cells in [3H]-thymidine incorporation assay

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Biochem/physiol Actions

TCA might act as a carcinogen, targeting liver. It might be used as an acid decalcifying agent. TCA helps in nuclear staining.

pictograms

CorrosionEnvironment

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8B - Non-combustible, corrosive hazardous materials

wgk_germany

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

> 113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Circulating fibrocytes stabilize blood vessels during angiogenesis in a paracrine manner
Li J, et al.
The American Journal of Pathology, 184(2), 556-571 (2014)
Rapid analysis of total plasma homocysteine by tandem mass spectrometry
Tuschl K, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 351(1-2), 139-141 (2005)
Analysis of malondialdehyde, chlorophyll proline, soluble sugar, and glutathione content in Arabidopsis seedling
Zhang Z and Huang R
Bio-protocol, 3, e817-e817 (2013)
Histophatologic Techniques (2006)
Bo Chen et al.
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The transient receptor potential melastatin 4 (TRPM4) channel has been suggested to play a key role in the treatment of ischemic stroke. However, in vivo evaluation of TRPM4 channel, in particular by direct channel suppression, is lacking. In this study

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