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34998

Sigma-Aldrich

Acetonitrile

HPLC Plus, ≥99.9%

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Synonym(s):
ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
Linear Formula:
CH3CN
CAS Number:
Molecular Weight:
41.05
Beilstein/REAXYS Number:
741857
EC Number:
MDL number:
eCl@ss:
39031501
PubChem Substance ID:
NACRES:
NA.03

grade

HPLC Plus

Quality Level

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

baseline drift measuring range

≤12 mAU (210 nm)

technique(s)

HPLC: suitable
IR spectroscopy: suitable

impurities

≤0.0001% free alkali (as NH3)
≤0.0002% non-volatile matter
≤0.001% free acid (as CH3COOH)
≤0.01% water (Karl Fischer)
≤0.5 ppb fluorescence (quinine) at 254 nm
≤0.5 ppb fluorescence (quinine) at 365 nm

halogenated residue

10 ng/L (as heptachlor epoxide)

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

density

0.786 g/mL at 25 °C (lit.)

HPLC-gradient

≤0.2 mAU at 254 nm
≤1 mAU at 210 nm

λ

H2O reference

UV absorption

λ: 195 nm Amax: ≤0.10
λ: 200 nm Amax: ≤0.02
λ: 228 nm Amax: ≤0.005
λ: 235 nm Amax: ≤0.0044
λ: 250 nm Amax: ≤0.0044
λ: 400 nm Amax: ≤0.0044

application(s)

food and beverages

format

neat

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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1 of 4

This Item
34851900667439134
vibrant-m

34998

Acetonitrile

vibrant-m

34851

Acetonitrile

vibrant-m

900667

Acetonitrile

vibrant-m

439134

Acetonitrile

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

assay

≥99.9%

assay

≥99.9%

assay

≥99.92%

assay

≥99.9%

grade

HPLC Plus

grade

gradient grade

grade

-

grade

gradient grade

autoignition temp.

973 °F

autoignition temp.

973 °F

autoignition temp.

973 °F

autoignition temp.

973 °F

technique(s)

HPLC: suitable, IR spectroscopy: suitable

technique(s)

HPLC: suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

HPLC: suitable, UV/Vis spectroscopy: suitable

General description

Acetonitrile (MeCN) is widely employed as a solvent in various studies and has high dielectric constant (37.5). Various purification procedures to obtain different grades of acetonitrile for use in different studies (polarography, spectroscopy, etc.) have been reported by many researchers.

Application

Acetonitrile has been used to compose the gradient system for the HPLC detection of diphenylmethane diisocyanate, a polymeric degradation product.
New Quality UPLC Plus Acetonitrile is suitable for all applications including:
Mass spectrometry, HPLC, TLC, GPC, UV, IR, GC, Pesticide Residue Analysis, and RNA/DNA Synthesis and Purification.

Preparation Note

Product filtered through a 0.2 μm filter

Other Notes

Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.
Important notice
  • The article number 34998-4X2.5L will be discontinued. Please order the single bottle 34998-2.5L which is physically identical with the same exact specifications.
  • The article number 34998-6X1L will be discontinued. Please order the single bottle 34998-1L which is physically identical with the same exact specifications.

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup


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H Haugen et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 73(2), 229-237 (2005-03-10)
This article deals with enzyme-induced biodegradation behavior of thermoplastic polyether-urethane (TPU). Porous scaffolds were processed by a new foaming method applied in hot pressing and injection molding. The scaffolds were subsequently gamma sterilized. The samples were incubated with cholesterol esterase
Alexander David Ardianrama et al.
Journal of colloid and interface science, 552, 485-493 (2019-06-04)
Although triangular silver (Ag) nanoplates are intrinsically unstable, this characteristic has been taken advantage of in the development of a novel sensing platform. However, most of these applications have relied on halide ions as etchants. In the current work, we
Purification of acetonitrile.
Walter M and Ramaley L.
Analytical Chemistry, 45(1), 165-166 (1973)
Timo Glatter et al.
Molecular systems biology, 5, 237-237 (2009-01-22)
Protein complexes represent major functional units for the execution of biological processes. Systematic affinity purification coupled with mass spectrometry (AP-MS) yielded a wealth of information on the compendium of protein complexes expressed in Saccharomyces cerevisiae. However, global AP-MS analysis of
Divya Subramonian et al.
Journal of proteome research, 13(9), 3905-3918 (2014-07-30)
SUMOylation is an essential posttranslational modification and regulates many cellular processes. Dysregulation of SUMOylation plays a critical role in metastasis, yet how its perturbation affects this lethal process of cancer is not well understood. We found that SUMO-2/3 modification is

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