496219
N,N-Diisopropylethylamine
99.5%, biotech. grade
Synonym(s):
N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine, ‘Hünig’s base’
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About This Item
Linear Formula:
[(CH3)2CH]2NC2H5
CAS Number:
Molecular Weight:
129.24
EC Number:
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.21
grade:
biotech. grade
assay:
99.5%
application(s):
peptide synthesis
bp:
127 °C (lit.)
vapor pressure:
31 mmHg ( 37.7 °C)
Pricing and availability is not currently available.
Recommended Products
grade
biotech. grade
vapor pressure
31 mmHg ( 37.7 °C)
assay
99.5%
form
liquid
impurities
<0.050% water
color
APHA: <20
refractive index
n20/D 1.414 (lit.)
pH
12.3 (20 °C)
bp
127 °C (lit.)
mp
<−50 °C (lit.)
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General description
N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.
N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.
Application
N, N-Diisopropylethylamine can be used as a base:
- In the palladium (0)-catalyzed alkoxy carbonylation of allyl phosphates and acetate.
- In the selective enolate formation along with boryl triflates.
- In the C–N coupling of aryl halides with nitroarenes in the presence of nickel catalyst.
N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.[1]
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
49.1 °F
flash_point_c
9.5 °C
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