246R-1
E-cadherin (EP700Y) Rabbit Monoclonal Primary Antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP700Y, monoclonal
Application:
IHC (p)
Citations:
9
biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
EP700Y, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (246R-14), vial of 0.5 mL concentrate (246R-15), bottle of 1.0 mL predilute (246R-17), vial of 1.0 mL concentrate (246R-16), bottle of 7.0 mL predilute (246R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
isotype
IgG
control
breast
shipped in
wet ice
storage temp.
2-8°C
visualization
membranous
General description
E-cadherin is a transmembrane protein that is involved in cell adhesion through the formationof adherens junctions between cells. It is expressed in cells of epithelial lineage. Anti-E-cadherin stains positively in the glandular epithelium as well as carcinomas of the gastrointestinaltract and breast. E-cadherin immunohistochemistry may also aid in the differentiation ofbreast ductal carcinomas (with membranous stain) from lobular carcinomas (with loss of themembranous stain).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
E-cadherin Positive Control Slides, Product No. 246S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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G Acs et al.
American journal of clinical pathology, 115(1), 85-98 (2001-02-24)
We studied the pattern of E-cadherin expression in 183 invasive carcinomas (100 ductal, 42 lobular, 41 with mixed ductal and lobular features) and 198 in situ carcinomas (131 ductal, 53 lobular, 14 in situ with ductal and lobular features) by
Amer Wahed et al.
Annals of diagnostic pathology, 6(6), 349-351 (2002-12-13)
Pleomorphic lobular carcinoma is a recently described entity separated from classical lobular carcinoma by cytologic pleomorphism. It can have an aggressive clinical course with a higher frequency of recurrence. Histologic differentiation with ductal carcinoma may be difficult, but it is
A C Han et al.
Cancer, 87(2), 83-86 (1999-05-05)
Cadherins are a family of cell-cell adhesion proteins. The homotypic binding of cadherins is critical for cell sorting and tissue formation during organogenesis. Different cadherin subtypes show lineage specific tissue expression, which has been exploited to differentiate histologically similar tumors
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 246R-14 | 0841683130031 |
| 246R-16 | 0841683130055 |
| 246R-15 | 0841683130048 |
| 246R-17 | 0841683130062 |
| 246R-18 | 0841683130079 |