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275R-1

Sigma-Aldrich

Ki-67 (SP6) Rabbit Monoclonal Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

SP6, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (275R-14)
vial of 0.5 mL concentrate (275R-15)
bottle of 1.0 mL predilute (275R-17)
vial of 1.0 mL concentrate (275R-16)
bottle of 7.0 mL predilute (275R-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... MKI67(4288)

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This Item
AB9260P6834453R-1
vibrant-m

AB9260

Anti-Ki-67 Antibody

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

clone

SP6, monoclonal

clone

polyclonal

clone

PP-67, monoclonal

clone

SP5, monoclonal

antibody form

culture supernatant

antibody form

affinity isolated antibody

antibody form

ascites fluid

antibody form

culture supernatant

species reactivity

human

species reactivity

mouse, human

species reactivity

human

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

immunoblotting: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:800 using microwave-treated human tonsil sections, microarray: suitable

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

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General description

The Ki-67 antigen is a nuclear, non-histone protein that is present in proliferatingcells. Though its specific role is largely postulated and still yet to be determined,Ki-67’s presence during cellular division makes it an excellent target for labeling rapidlygrowing malignancies. Given that its presence correlates with cell proliferation, theimmunohistochemical labeling of Ki-67 antigen may be useful in characterizing a lesion’sgrowth fraction.

Quality


IVD

IVD

IVD

RUO

Linkage

Ki-67 Positive Control Slides, Product No. 275S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Nirmala Pathmanathan et al.
Journal of clinical pathology, 66(6), 512-516 (2013-02-26)
New approaches to the prognostic assessment of breast cancer have come from molecular profiling studies. A major feature of this work has been to emphasise the importance of cancer cell proliferation as a key discriminative indicator of recurrence risk for
Swerdlow S, et al. WHO clarifications of tumours of hematopoietic and lymphoid tissues. 4th edition, 2008. P 220.
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue, 220-220 (2008)
Ran Marciano et al.
Cancers, 11(2) (2019-02-02)
Tumor cells utilize glucose to fuel their anabolic needs, including rapid proliferation. However, due to defective vasculature and increased glucose uptake, tumor cells must overcome glucose deprivation. Accordingly, tumor cells depend on cellular pathways promoting survival under such conditions. Targeting
S W Coons et al.
Neurosurgery, 41(4), 878-884 (1997-10-08)
The prognostic significance of quantitative measurement of tumor proliferative activity was evaluated for oligodendroglial tumors. Ki-67/MIB-1 immunochemistry was used to measure proliferative activity in 81 oligodendrogliomas and oligoastrocytomas. The relationship among survival, proliferation, histological features, and clinical variables were evaluated
P E McKeever et al.
Journal of neuropathology and experimental neurology, 57(10), 931-936 (1998-10-24)
The purpose of this study was to determine whether a relationship existed between MIB-1 labeling index (LI) percentages and survival in patients with grade II astrocytomas. From archival paraffin-embedded surgical specimens of 50 patients of the University of Michigan Medical

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3D cell culture protocol for generating epidermal human skin tissue using primary human keratinocytes, dermal fibroblasts, and collagen-coated transwell inserts.

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