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MilliporeSigma
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Key Documents

308M-1

Sigma-Aldrich

Oct-2 (MRQ-2) Mouse Monoclonal Antibody

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1 ML
$171.00
0.1 ML
$213.00
7 ML
$348.00
0.5 ML
$522.00
1 ML
$814.00

$171.00


Estimated to ship onMarch 25, 2025


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1 ML
$171.00
0.1 ML
$213.00
7 ML
$348.00
0.5 ML
$522.00
1 ML
$814.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

clone:
MRQ-2, monoclonal
application:
IHC (p)
species reactivity:
human
technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
citations:
4

$171.00


Estimated to ship onMarch 25, 2025


Request a Bulk Order

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

MRQ-2, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (308M-14)
vial of 0.5 mL concentrate (308M-15)
bottle of 1.0 mL predilute (308M-17)
vial of 1.0 mL concentrate (308M-16)
bottle of 7.0 mL predilute (308M-18)

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1 of 4

This Item
309M-1382M-1120M-8
clone

MRQ-2, monoclonal

clone

MRQ-10, monoclonal

clone

MRQ-58, monoclonal

clone

L26, monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody form

diluted ascites fluid

antibody form

culture supernatant

antibody form

diluted ascites fluid

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Octamer-binding transcription factor-2 (Oct-2) is a transcription factor of the POU homeo-domain family. It binds to Ig gene octamer sites and plays a crucial role in B-cell development and differentiation, as well as in B-cell identity.[1] Oct-2 is expressed in a subset of normal B-lymphocytes and is expressed in various B-cell lymphomas as well as nodular lymphocyte predominant Hodgkin lymphoma, while it is typically not expressed in the Reed–Sternberg and Hodgkin (RS/H) cells of classical Hodgkin lymphoma.[1]


Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and despite the scarce evidence for Oct-2 expression in T cells, it has been shown that this factor participates in transcriptional regulation during T-cell activation. Oct-2 activity is dependent on phosphorylation and alternatitive splicing, although it seems that the level of its expression can be used as a marker of B-cell lineage and differentiation. The following show high levels of Oct-2 expression: germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells. Various lymphomas are also positive for this marker including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, classic Hodgkin lymphoma.

Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines display high levels of expression. Analysis of Oct-2 expression in primary Hodgkin’s lymphoma (HLs) and cell lines derived from it showed that the tumor cells analyzed had high levels of expression and activity, suggesting a common B-cell origin for all types of HLs.

Associated products: bcl-6, CD20, CD79a, PAX-5, BOB.1

Quality


IVD

IVD

IVD

RUO

Linkage

Oct-2 Positive Control Slides, Product No. 308S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Mónica García-Cosío et al.
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 17(12), 1531-1538 (2004-07-17)
    Hodgkin's lymphoma can be considered in most cases a B-cell lymphoma due to the presence of potentially functional immunoglobulin (Ig) gene rearrangements in the neoplastic cells. In contrast to lymphocyte-predominant Hodgkin's lymphoma, Hodgkin/Reed-Sternberg (HRS) cells from classical Hodgkin's lymphoma have
    Christian Hallermann et al.
    Journal of the American Academy of Dermatology, 56(4), 588-597 (2007-02-10)
    There is a growing body of literature that has enhanced our understanding of the biology of primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) including in the context of gene profiling studies. Recent studies have demonstrated an activated proliferation profile associated
    Sarah E Gibson et al.
    American journal of clinical pathology, 126(6), 916-924 (2006-11-01)
    The aberrant expression of the B-cell transcription factor PAX5 has been described in a subset of acute myeloid leukemia (AML) with t(8;21)(q22;q22) in association with B-cell antigen expression. However, the expression of other B cell-associated transcription factors, particularly OCT-2 and
    Patrick Browne et al.
    American journal of clinical pathology, 120(5), 767-777 (2003-11-12)
    Even with routine immunohistochemical evaluation, distinguishing classic Hodgkin lymphoma (CHL) from diffuse large B-cell lymphoma (DLBCL) or anaplastic large cell lymphoma (ALCL) can be difficult. In these cases, the transcription factors (B cell-specific activator protein [BSAP], octamer-binding transcription factor 2

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