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348M-9

Sigma-Aldrich

WT1 (6F-H2) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

6F-H2, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (348M-94)
vial of 0.5 mL concentrate (348M-95)
bottle of 1.0 mL predilute (348M-97)
vial of 1.0 mL concentrate (348M-96)
bottle of 7.0 mL predilute (348M-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1κ

control

kidney, mesothelioma, ovarian carcinoma (serous), testis

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... WT1(7490)

General description

Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed intissues of mesodermal origin. The Wilms’ tumor gene encodes a protein that functionsas a tumor suppressor gene mapped to human chromosome 11p13.2 Nuclear WT1immunoreactivity has been observed in high frequencies in several types of mesoderm-derived tumors including epithelioid mesothelioma and ovarian serous carcinoma and thus isused as a marker for these neoplasms.

Quality


IVD
IVD
IVD
RUO

Linkage

WT-1 Positive Control Slides, Product No. 348S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alberto M Marchevsky
Archives of pathology & laboratory medicine, 132(3), 397-401 (2008-03-06)
The diagnosis of malignant mesothelioma (MM) is rendered with the aid of immunohistochemistry to demonstrate the presence of "mesothelial," "epithelial," or "sarcomatous" differentiation. Antibody panels that have been proposed for the distinction between MM and other neoplasms usually include 2
Rena J May et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(15 Pt 1), 4547-4555 (2007-08-03)
Wilms' tumor 1 protein (WT1), a transcription factor overexpressed in malignant mesothelioma, leukemias, and other solid tumors, is an ideal target for immunotherapy. WT1 class I peptide epitopes that were identified and shown to stimulate CD8(+) T cells are being
M A Ghanem et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 6(11), 4265-4271 (2000-12-06)
Wilms' tumor is one of the most common solid tumors of children. The protein product of the tumor-suppressor gene, Wilms' tumor 1 (WT-1), binds to the same DNA sequences as the protein product of the early growth response 1 (EGR-1)
R Barnoud et al.
The American journal of surgical pathology, 24(6), 830-836 (2000-06-08)
Desmoplastic small round cell tumors (DSRCTs) present a reciprocal chromosomal translocation, t(11;22)(p13;q12), that results in fusion of Ewing's sarcoma and Wilms' tumor (WT1) genes. The authors evaluated 15 DSRCTs and 71 other tumors often considered in the differential diagnosis for
Nelson G Ordóñez
Archives of pathology & laboratory medicine, 129(11), 1407-1414 (2005-10-29)
Several new immunohistochemical markers that can assist in the diagnosis of mesotheliomas have been recognized recently. This article reviews the current information available on these markers and also provides a practical approach to the immunohistochemical diagnosis of epithelioid mesotheliomas. Current
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