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462R-1

Sigma-Aldrich

SF-1 (EP434) Rabbit Monoclonal Primary Antibody

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Synonym(s):
Steroidogenic Factor-1

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP434, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (462R-14)
vial of 0.1 mL concentrate Research Use Only (462R-14-RUO)
vial of 0.5 mL concentrate (462R-15)
vial of 1.0 mL concentrate (462R-16)
vial of 1.0 mL concentrate Research Use Only (462R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (462R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (462R-17)
vial of 7.0 mL pre-dilute ready-to-use (462R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (462R-18-RUO)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

adrenocortical carcionma, granulosa cell tumor, testis

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... SF1(7536)

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07-618207R-1442R-1
Anti-SF-1 Antibody Upstate®, from rabbit

07-618

Anti-SF-1 Antibody

species reactivity

human

species reactivity

mouse

species reactivity

human

species reactivity

human

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

culture supernatant

antibody form

purified immunoglobulin

antibody form

culture supernatant

antibody form

culture supernatant

clone

EP434, monoclonal

clone

polyclonal

clone

EP257, monoclonal

clone

EP310, monoclonal

form

buffered aqueous solution

form

-

form

buffered aqueous solution

form

buffered aqueous solution

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General description

As both a nuclear receptor and nuclear transcription factor, Steroidogenic factor-1 (SF-1) serves as an important modulator of steroidogenesis. It has been demonstrated that SF-1 serves as a “master regulator” in varying facets of development and function in both reproductive and adrenal tissues. Immunohistochemical detection of SF-1 in testicular tissue may provide value for distinguishing sex-cord stromal tumors, including Leydig cell, Sertoli cell and granulosa cell neoplasms, from other tumors. In addition, SF-1 detection may have utility in distinguishing primary adrenal cortical lesions from their histologic mimics such as renal clear cell carcinoma.

Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Ranna El-Khairi et al.
Seminars in reproductive medicine, 30(5), 374-381 (2012-10-10)
Steroidogenic factor-1 (SF-1) (Ad4BP, NR5A1) is a nuclear receptor that plays a key role in adrenal and reproductive development and function. Deletion of the gene encoding Sf-1 (Nr5a1) in mice results in severe developmental defects of the adrenal gland and
Ankur R Sangoi et al.
The American journal of surgical pathology, 35(5), 678-686 (2011-04-15)
The diagnosis of metastatic clear cell renal cell carcinoma (CC-RCC) can be difficult because of its morphologic heterogeneity and the increasing use of small image-guided biopsies that yield scant diagnostic material. This is further complicated by the degree of morphologic
Chengquan Zhao et al.
The American journal of surgical pathology, 33(3), 354-366 (2008-11-27)
Different immunohistochemical sex cord-stromal markers have been previously studied in various types of ovarian sex cord-stromal tumors; however, the sensitivity for sex cord-stromal lineage may vary between markers, and some markers may not be as sensitive in some types of
Ankur R Sangoi et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(4), 318-321 (2012-11-21)
Differentiating testicular germ cell tumors from sex-cord stromal tumors can be difficult in certain cases because of overlapping morphologic features and/or an absence of clinically apparent hormonal symptoms. Immunohistochemistry may be needed as an ancillary diagnostic tool in this differential

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