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466R-1

Sigma-Aldrich

SDHB (EP288) Rabbit Monoclonal Primary Antibody

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Synonym(s):
Succinate dehydrogenase B

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP288, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (466R-14)
vial of 0.1 mL concentrate Research Use Only (466R-14-RUO)
vial of 0.5 mL concentrate (466R-15)
vial of 1.0 mL concentrate (466R-16)
vial of 1.0 mL concentrate Research Use Only (466R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (466R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (466R-17)
vial of 7.0 mL pre-dilute ready-to-use (466R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (466R-18-RUO)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

GIST

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... SDHB(6390)

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ABC835MABN627384R-1
vibrant-m

ABC835

Anti-SDHD Antibody

vibrant-m

MABN627

Anti-SDHB Antibody, clone 10C5.1

species reactivity

human

species reactivity

mouse

species reactivity

human, mouse

species reactivity

human

antibody form

culture supernatant

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

culture supernatant

conjugate

unconjugated

conjugate

-

conjugate

-

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

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General description

Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas (RCC) and gastrointestinal stromal tumors (GIST). However, a subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Anthony J Gill et al.
Human pathology, 41(6), 805-814 (2010-03-20)
Up to 30% of pheochromocytomas and paragangliomas are associated with germline RET, Von Hippel-Lindau (VHL), neurofibromatosis type I (NF1), and succinate dehydrogenase subunits (SDHB, SDHC, and SDHD) mutations. Genetic testing allows familial counseling and identifies subjects at high risk of
H C Au et al.
Gene, 159(2), 249-253 (1995-07-04)
The iron-sulfur protein (Ip) subunit of succinate dehydrogenase (SDH and complex II) of the respiratory chain is highly conserved in evolution [Gould et al., Proc. Natl. Acad. Sci. USA 86 (1989) 1934-1938]. We have cloned the entire human Ip cDNA
Sean R Williamson et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(1), 80-94 (2014-07-19)
Patients with germline mutation of succinate dehydrogenase (SDH) subunit genes are prone to develop paraganglioma, gastrointestinal stromal tumor, and rarely renal cell carcinoma (RCC). However, SDH-deficient RCC is not yet widely recognized. We identified such tumors by distinctive morphology and
José Gaal et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(1), 147-151 (2010-10-05)
Mutations in the tumor suppressor genes SDHB, SDHC, and SDHD (or collectively SDHx) cause the inherited paraganglioma syndromes, characterized by pheochromocytomas and paragangliomas. However, other tumors have been associated with SDHx mutations, such as gastrointestinal stromal tumors (GISTs) specifically in

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