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387R-1

Sigma-Aldrich

Olig2 (EP112) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP112, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (387R-17)
bottle of 7.0 mL predilute (387R-18)
vial of 0.1 mL concentrate (387R-14)
vial of 0.5 mL concentrate (387R-15)
vial of 1.0 mL concentrate (387R-16)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... OLIG2(10215)

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387M-1ABN899MABN50
Anti-Olig-2 Antibody from rabbit, purified by affinity chromatography

ABN899

Anti-Olig-2 Antibody

Anti-Olig2 Antibody, clone 211F1.1 clone 211F1.1, from mouse

MABN50

Anti-Olig2 Antibody, clone 211F1.1

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

conjugate

-

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

mouse

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

species reactivity

human

species reactivity

human

species reactivity

mouse, rat, human

species reactivity

mouse

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

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General description

Olig2, a basic helix–loop–helix transcription factor, is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas.1-2 More than half of glioblastomas are weakly positive for Olig2. No Olig2 expression has been found in the non-glial tumors including neuroepithelial tumors, ependymomas, subependymomas, medulloblastomas, and nonneuroepithelial tumors, such as CNS lymphomas, meningiomas, schwannomas, atypical teratoid/rhabdoid tumor, and haemangioblastomas.1-2 In order to characterize cellular subtypes that constitute astrocytomas, oligoastrocytomas and oligodendrogliomas, double labeling of Olig2 and GFAP has been performed which identified two phenotypically distinct tumor populations. The first is Olig2+/GFAP– which has an oligodendroglial morphology, corresponding to pure oligodendrogliomas that contain only oligodendroglial cells; the second is Olig2–/GFAP+ which has an astrocytic phenotype, including not only oligoastrocytomas, but also WHO astrocytomas.1-2

Quality


IVD

IVD

IVD

RUO

Linkage

Olig2 Positive Control Slides, Product No. 387S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Dazhi Guo et al.
Molecular neurobiology, 60(3), 1675-1689 (2022-12-23)
A disintegrin and metalloproteinase 10 (ADAM10) plays an essential role in the regulation of survival, proliferation, migration, and differentiation of various neural cells. Nevertheless, the role of ADAM10 in oligodendrocyte precursors (OPCs) and myelination in the central nervous system (CNS)
K Mokhtari et al.
Neuropathology and applied neurobiology, 31(1), 62-69 (2005-01-07)
The expression of Olig2, a basic helix-loop-helix (bHLH) transcription factor involved in oligodendroglial specification, was investigated by immunohistochemistry in a series of 146 tumours and control samples. Olig2 expression was restricted to glial tumours and nontumoral oligodendrocytes. It was higher
José Javier Otero et al.
Journal of neuro-oncology, 104(2), 423-438 (2011-01-05)
The bHLH transcription factor, OLIG2, is universally expressed in adult human gliomas and, as a major factor in the development of oligodendrocytes, is expressed at the highest levels in low-grade oligodendroglial tumors. In addition, it is functionally required for the

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