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258R-2

Sigma-Aldrich

Glial Fibrillary Acidic Protein (GFAP) (SP78) Rabbit Monoclonal Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

SP78, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (258R-24)
vial of 0.5 mL concentrate (258R-25)
bottle of 1.0 mL predilute (258R-27)
vial of 1.0 mL concentrate (258R-26)
bottle of 7.0 mL predilute (258R-28)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

control

brain

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... GFAP(2670)

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This Item
258R-1MAB3402BAB5541
conjugate

unconjugated

conjugate

unconjugated

conjugate

biotin conjugate

conjugate

-

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

purified antibody

antibody form

affinity isolated antibody

clone

SP78, monoclonal

clone

EP672Y, monoclonal

clone

monoclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

-

form

-

species reactivity

human

species reactivity

human

species reactivity

pig, mouse

species reactivity

human, mouse, rat, bovine, pig

General description

Anti-GFAP antibody detects astrocytes, Schwann cells, satellite cells, enteric glial cells, and some groups of ependymal cells. This marker is mainly used to distinguish neoplasms of astrocytic origin from other neoplasms in the central nervous system.

Linkage

GFAP Positive Control Slides, Product No. 258S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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E Kawahara et al.
The American journal of surgical pathology, 12(2), 115-120 (1988-02-01)
Immunoreactivity of glial fibrillary acidic protein (GFAP) in 38 schwannomas and 18 neurofibromas was evaluated and compared with the reactivity of vimentin, S-100 protein, and neurofilament protein. All cases were positive for vimentin and S-100 protein. GFAP was positively stained
Goro Nagashima et al.
Clinical neurology and neurosurgery, 104(2), 125-131 (2002-04-05)
To investigate the mechanisms of proteolysis within the glioma, and tissue reactions against glioblastoma, immunohistochemical detection both outside and inside of the tumor was performed using seven brains with glioblastoma that were obtained from autopsies. Immunohistochemistry was performed to detect
K R Jessen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 3(11), 2206-2218 (1983-11-01)
The similarities between the enteric nervous system of the gut and the central nervous system (CNS), both of which function as complex integrative nervous networks, include striking ultrastructural similarities between the glia of the enteric nervous system and the astrocytic
F Giangaspero et al.
Acta neuropathologica, 103(2), 152-156 (2002-01-26)
We report on two children with cerebral gliomas showing extensive lipomatous change of tumor cells. One tumor was a large mass occupying the temporal and occipital lobes of the left hemisphere; the other was a cystic lesion with a mural
B H Choi et al.
Science (New York, N.Y.), 223(4634), 407-409 (1984-01-27)
In the human fetal spinal cord at 15 to 16 weeks, glial fibrillary acidic protein (GFAP) was demonstrated within the cytoplasm and processes of cells having the cytological, ultrastructural, and immunocytochemical features of oligodendrocytes--including processes that extend into and contribute

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