402RA-05A

Human Chondrocytes - Rheumatoid Arthritis: HC-RA, adult

• UNSPSC Code: 41106514
• NACRES: NA.81

Properties

• biological source: human articular cartilage (rheumatoid arthritic)
• Quality Level: 100
• packaging: pkg of 500,000 cells
• manufacturer/tradename: Cell Applications, Inc
• growth mode: Adherent
• karyotype: 2n = 46
• morphology: chondrocyte
• technique(s): cell culture | mammalian: suitable
• relevant disease(s): arthritis
• shipped in: dry ice
• storage temp.: −196°C

Description

General description

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HC-RA Human Chondrocytes are derived from human articular cartilage of donors with rheumatoid arthritis (RA). Rheumatoid arthritis is an inflammatory disease that is characterized by overproliferation of synovial cells and their infiltration into adjacent joint tissues, accompanied by gradual destruction of cartilage and bone erosion. Normally, chondrocytes are responsible for producing and maintaining the extracellular matrix of cartilage, but in RA cartilage, the environment is changed significantly due to inflammation and the invasion of other cells. Therefore, HC-RA can be a useful model to study the effects of those changes on chondrocyte biology. In parallel with normal HC, HC-RA can be used to investigate the differences between normal and pathological joints and evaluate potential treatment strategies.

Characterization: Positive for aggrecan after differentiation.

Cell Line Origin

Cartilage

Application

model to study effects of RA on chondrocytes, investigate differences between normal and pathological joints and evaluate potential treatment strategies

Components

Basal Medium containing 10% FBS & 10% DMSO

Preparation Note

• 1st passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
• Can be cultured at least 10 doublings

Subculture Routine

Please refer to the HC-RA Culture Protocol.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable