62962

L-α-Lysophosphatidylcholine

egg yolk, ≥99.0% (TLC)

• Synonym(s): 3-sn-Lysophosphatidylcholine, L-α-Lysolecithin
• MDL number: MFCD00131444
• UNSPSC Code: 51321705
• NACRES: NA.25

Properties

• biological source: egg yolk
• description: zwitterionic
• assay: ≥99.0% (TLC)
• form: powder or solid
• composition: 16:0, ~69% (fatty acid); 18:0, ~27% (fatty acid); 18:1, ~3% (fatty acid)
• solubility: chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow
• functional group: phospholipid
• lipid type: phosphoglycerides
• shipped in: wet ice
• storage temp.: −20°C

Description

Application

• The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014).


• Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005).

Biochem/physiol Actions

3-sn-Lysophosphatidylcholine, besides contributing to the positive curvature of membranes , inhibits SNARE complex disassembly in vitro and in rat nerve terminals and exocrine pancrease .

Other Notes

Preparation of demembranated frog sperm chromatin

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)