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L4129

Sigma-Aldrich

L-α-Lysophosphatidylcholine from egg yolk

≥99%, Type I, powder

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Synonym(s):
1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
CAS Number:
EC Number:
MDL number:
NACRES:
NA.25

biological source

egg yolk

description

zwitterionic

type

Type I

Assay

≥99%

form

powder

color

white

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

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This Item
Y000190413720501372061
Lysophosphatidylcholine United States Pharmacopeia (USP) Reference Standard

USP

1372050

Lysophosphatidylcholine

USP

USP

1372061

Lysophosphatidylcholine (Soy)

description

zwitterionic

description

-

description

-

description

-

assay

≥99%

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

Application

L-α-Lysophosphatidylcholine from egg yolk has been used:
  • as a surfactant
  • as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
  • as a demyelinating agent for nerve
  • as a component in sperm nuclei preparation buffer

Biochem/physiol Actions

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.

Quality

Contains primarily palmitic and stearic acids.

Preparation Note

Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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In this work a new MRI modality entitled Relaxation Along a Fictitious Field in the rotating frame of rank 4 (RAFF4) was evaluated in its ability to detect lower myelin content in lysophosphatidyl choline (LPC)-induced demyelinating lesions. The lesions were
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