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74667

Sigma-Aldrich

Nourseothricin sulfate

≥85% (HPLC)

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CAS Number:
MDL number:
NACRES:
NA.85

biological source

Streptomyces noursei

Assay

≥85% (HPLC)

form

solid

color

white to light brown

solubility

H2O: soluble 200 mg/mL

suitability

suitable for (selection agent for molecular genetic research work)

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi
mycobacteria
mycoplasma
parasites
viruses
yeast

Mode of action

protein synthesis | interferes

storage temp.

2-8°C

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This Item
N0186N8028P9620
Sigma-Aldrich

Sigma-Aldrich

74667

Nourseothricin sulfate

Sigma-Aldrich

Sigma-Aldrich

N0186

Nourseothricin sulfate

assay

≥85% (HPLC)

assay

-

assay

≥90% (HPLC)

assay

>98% (HPLC)

form

solid

form

powder

form

powder

form

solution

color

white to light brown

color

-

color

-

color

-

solubility

H2O: soluble 200 mg/mL

solubility

-

solubility

H2O: soluble 5 mg/mL

solubility

H2O: soluble 10 mg/mL

suitability

suitable for (selection agent for molecular genetic research work)

suitability

-

suitability

-

suitability

-

General description

Chemical structure: peptidyl nucleoside

Application

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

Biochem/physiol Actions

Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.

Packaging

10mg, 100mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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