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A2522

Sigma-Aldrich

Actin from rabbit muscle

≥85% (SDS-PAGE), lyophilized powder

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Synonym(s):
Alpha-actin 1, G-Actin
CAS Number:
MDL number:
NACRES:
NA.32

biological source

rabbit

Quality Level

assay

≥85% (SDS-PAGE)

form

lyophilized powder

mol wt

43 kDa

composition

Protein, ≥80% biuret

technique(s)

immunoblotting: suitable

UniProt accession no.

storage temp.

2-8°C

Gene Information

rabbit ... LOC(100342017)

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This Item
A3653A2066SAB4200689
Sigma-Aldrich

A2522

Actin from rabbit muscle

Sigma-Aldrich

A3653

Actin from bovine muscle

biological source

rabbit

biological source

bovine muscle

biological source

rabbit

biological source

mouse

assay

≥85% (SDS-PAGE)

assay

≥90% (SDS-GE)

assay

-

assay

-

mol wt

43 kDa

mol wt

43 kDa

mol wt

antigen 42 kDa

mol wt

antigen ~42 kDa

form

lyophilized powder

form

lyophilized powder

form

buffered aqueous solution

form

buffered aqueous solution

Gene Information

rabbit ... LOC(100342017)

Gene Information

bovine ... LOC(528168)

Gene Information

human ... ACTA1(58)
mouse ... Acta1(11459)
rat ... Acta1(29437)

Gene Information

human ... ACTA2(59)

General description

Actin is the abundant protein found in many cells which accounts for 10% or more of total protein. Most of the eukaryotic cells shows the presence of actin protein. Outer and inner domains are the two important domains of actin.

Application

Actin from rabbit muscle has been used:
  • to study its protective role on rabbit muscle lactate dehydrogenase from ascorbate inhibition
  • as standard in SDS gel and immunoblotting
  • in the protein pin array assays

Biochem/physiol Actions

Actin plays a key role in protein-protein interactions. It participates in cell motility, cell shape maintenance and polarity to the regulation of transcription.

Physical form

Lyophilized powder containing Tris, ATP and CaCl2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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J A Henderson et al.
Endocrine, 33(3), 285-293 (2008-11-21)
To further understand the role of ovarian hormones in the function of the serotonin neural system, we investigated the effects of estradiol (E), progesterone (P), and raloxifene on 5HT 1A and 2C receptor protein expression in the dorsal raphe region
Pooneh Vaziri et al.
Genetics, 216(1), 177-190 (2020-08-06)
Myosin is an essential motor protein, which in muscle is comprised of two molecules each of myosin heavy-chain (MHC), the essential or alkali myosin light-chain 1 (MLC1), and the regulatory myosin light-chain 2 (MLC2). It has been shown previously that MLC2
Jarrod A Call et al.
Journal of applied physiology (Bethesda, Md. : 1985), 105(3), 923-932 (2008-06-28)
Duchenne muscular dystrophy is characterized by the absence of dystrophin from muscle cells. Dystrophic muscle cells are susceptible to oxidative stress. We tested the hypothesis that 3 wk of endurance exercise starting at age 21 days in young male mdx
Desmin cytoskeletal modifications after a bout of eccentric exercise in the rat
Barash IA, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 91-98 (2002)
Actin and Actin-Binding Proteins
Pollard TD, et al.
Cold Spring Harbor Perspectives in Biology, 8(8) (2016)

Articles

Although actin is one of the most conserved eukaryotic proteins, it is expressed as six isoforms characterized by electrophoresis and amino acid sequence analysis. Four of the six isoforms represent differentiation markers of muscle tissues. The other two are found in practically all cells.

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