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A5486

Sigma-Aldrich

Azoxymethane

13.4 M, ≥98%

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Synonym(s):
AOM
Linear Formula:
CH3N=N(→O)CH3
CAS Number:
Molecular Weight:
74.08
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Assay

≥98%

form

liquid

composition

methylene chloride, ≤1% (solvent)

concentration

13.4 M

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

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This Item
118502344906409081
Azoxymethane 13.4 M, ≥98%

Sigma-Aldrich

A5486

Azoxymethane

ATM Kinase Inhibitor InSolution, ≥95%

Sigma-Aldrich

118502

ATM Kinase Inhibitor

FURA 2/AM in Solution

Sigma-Aldrich

344906

FURA 2/AM in Solution

form

liquid

form

liquid

form

liquid

form

viscous liquid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

composition

methylene chloride, ≤1% (solvent)

composition

-

composition

-

composition

acrylamide, ~55 wt. %

concentration

13.4 M

concentration

-

concentration

-

concentration

10 wt. % in H2O

General description

Azoxymethane (AOM) is a potent laboratory chemical used to study cancer initiation, progression, and prevention, particularly in the colon. It acts as both a carcinogen, triggering tumor formation, and a gene mutation agent, causing specific alterations in DNA.

Application

Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.

Biochem/physiol Actions

Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

Features and Benefits

Versatile and adaptable for a wide variety of laboratory and research applications.

Other Notes

It is critical to determine the correct dosage of Azoxymethane for the experimental design to avoid premature death of laboratory animals.

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

75.2 °F

Flash Point(C)

24 °C


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