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A6566

Sigma-Aldrich

2-Hydroxysaclofen

≥98% (TLC), solid

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Synonym(s):
3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid
Empirical Formula (Hill Notation):
C9H12ClNO4S
CAS Number:
Molecular Weight:
265.71
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥98% (TLC)

form

solid

color

white

solubility

H2O: 1 mg/mL
0.1 M HCl: 1.2 mg/mL
methanol: 1.4 mg/mL
DMSO: 28 mg/mL
0.1 M NaOH: 9.5 mg/mL

SMILES string

NCC(O)(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)

InChI key

WBSMZVIMANOCNX-UHFFFAOYSA-N

Gene Information

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This Item
C8417M196B154
2-Hydroxysaclofen ≥98% (TLC), solid

A6566

2-Hydroxysaclofen

(+)-α-Methyl-4-carboxyphenylglycine solid

M196

(+)-α-Methyl-4-carboxyphenylglycine

BU224 hydrochloride solid

B154

BU224 hydrochloride

form

solid

form

solid

form

solid

form

solid

solubility

H2O: 1 mg/mL, methanol: 1.4 mg/mL, 0.1 M NaOH: 9.5 mg/mL, 0.1 M HCl: 1.2 mg/mL, DMSO: 28 mg/mL

solubility

H2O: 48 mg/mL, 0.1 M NaOH: 7 mg/mL, ethanol: soluble

solubility

0.1 M NaOH: 15 mg/mL

solubility

ethanol: 1.2 mg/mL, H2O: >16 mg/mL, 0.1 M NaOH: 24 mg/mL, 0.1 M HCl: >30 mg/mL

color

white

color

white

color

-

color

white

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

-

Gene Information

rat ... Grm1(24414)

Gene Information

-

Biochem/physiol Actions

Potent and selective antagonist at GABAB receptors.

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Fu-Sun Lo et al.
Journal of neurophysiology, 87(3), 1175-1185 (2002-03-06)
Using intracellular recordings in an isolated (in vitro) rat brain stem preparation, we examined the synaptic responses of developing relay neurons in the dorsal lateral geniculate nucleus (LGN). In newborn rats, strong stimulation of the optic tract (OT) evoked excitatory
P W Kalivas et al.
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This study evaluated the capacity of mu-opioid and glutamate receptor agonists to differentially regulate the involvement of the GABAergic projection from the ventral pallidum to the mediodorsal thalamus in working memory and locomotor activity. Microinjection of either the ionotropic glutamate
María M Bonaventura et al.
European journal of pharmacology, 677(1-3), 188-196 (2012-01-03)
γ-Aminobutyric acid (GABA) inhibits insulin secretion through GABA(B) receptors in pancreatic β-cells. We investigated whether GABA(B) receptors participated in the regulation of glucose homeostasis in vivo. BALB/c mice acutely pre-injected with the GABA(B) receptor agonist baclofen (7.5mg/kg, i.p.) presented glucose
Jacques H Abraini et al.
Anesthesia and analgesia, 96(3), 746-749 (2003-02-25)
Inhaled anesthetics, including the gaseous anesthetics nitrous oxide and xenon, are thought to act by interacting directly with ion-channel receptors. In contrast, little is known about the mechanism of action of inert gases that show only narcotic potency at high
Nonna A Otmakhova et al.
Journal of neurophysiology, 92(4), 2027-2039 (2004-05-28)
CA1 pyramidal cells receive two major excitatory inputs: the perforant path (PP) terminates in the most distal dendrites, whereas the Schaffer collaterals (SC) terminate more proximally. We have examined the mechanism of the afterhyperpolarization (AHP) that follows single subthreshold excitatory

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