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A6683

Sigma-Aldrich

L-Aspartic acid sodium salt monohydrate

≥98% (TLC)

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Synonym(s):
(S)-2-Aminobutanedioic acid sodium salt, Sodium L-aspartate
Linear Formula:
HO2CCH2CH(NH2)CO2Na · H2O
CAS Number:
Molecular Weight:
173.10
Beilstein/REAXYS Number:
6101944
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥98% (TLC)

form

powder

color

white

SMILES string

[Na+].[H]O[H].N[C@@H](CC(O)=O)C([O-])=O

InChI

1S/C4H7NO4.Na.H2O/c5-2(4(8)9)1-3(6)7;;/h2H,1,5H2,(H,6,7)(H,8,9);;1H2/q;+1;/p-1/t2-;;/m0../s1

InChI key

PPTHNBYUFXSJPS-JIZZDEOASA-M

Gene Information

human ... GRIN2A(2903)
rat ... GRIN2A(14811)

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1 of 4

This Item
1119511189A7219
vibrant-m

11189

L-Aspartic acid

Premium Grade
vibrant-m

A7219

L-Aspartic acid

-
assay

≥98% (TLC)

assay

≥99.0% (NT)

assay

≥99.5% (T)

assay

98.5-101.0%

color

white

color

white

color

white

color

white to off-white

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

Gene Information

human ... GRIN2A(2903)
rat ... GRIN2A(14811)

Gene Information

-

Gene Information

human ... CA1(759), CA2(760)
rat ... Grin2a(24409)

Gene Information

human ... CA1(759), CA2(760)
rat ... Grin2a(24409)

General description

Aspartic acid is a non-essential amino acid. L-Aspartic acid is a dicarboxylic amino acid, which is involved in the synthesis of nerve cells proteins. It also stimulates the depolarization of nerve cell membranes. L-Aspartic acid acts as an amine donor for transamination reaction.

Application

L-Aspartic acid sodium salt monohydrate has been as a component of reservoir solution for crystallization.

Biochem/physiol Actions

Selective outflow of L-aspartic acid across the blood-brain barrier controls the level of L and D aspartic acid in the brain. Increased levels of L-aspartic acid in the brain results in excitatory neurotoxicity. Recent studies highlight that racemization of L-aspartic acid is followed by the determination of D:L ratio to estimate the age of an individual.
Principal neurotransmitter for fast synaptic excitation.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Biocatalysis (2013)
Age estimation of living Indian individuals based on aspartic acid racemization from tooth biopsy specimen
Manu Rastogi
Journal of Forensic Sciences, 9(2), 83-90 (2017)
Structural insight into substrate selectivity of Erwinia chrysanthemi l-Asparaginase
Nguyen HA, et al.
Biochemistry, 55(8), 1246-1253 (2016)
The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood?brain barrier
Kazuhiro Tetsuka
Journal of Neurochemistry, 87(4), 891-901 (2003)
Design and characterization of erwinia chrysanthemi l-asparaginase variants with diminished l-glutaminase activity
Nguyen HA, et al.
The Journal of biological chemistry, 291(34), 17664-17676 (2016)

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