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A6955

Sigma-Aldrich

Angiogenin human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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Synonym(s):
ANG
MDL number:
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

mol wt

14.4 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... ANG(283)

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100

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200

Quality Level

200

Quality Level

-

biological source

human

biological source

human

biological source

human

biological source

human

assay

≥97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in HeLa cells

Gene Information

human ... ANG(283)

Gene Information

human ... VEGFB(7423)

Gene Information

human ... TNF(7124)

Gene Information

human ... ANGPT1(284)

General description

Angiogenin is a secreted growth factor. It is localized in the tissue fluids such as plasma, amniotic fluid, cerebrospinal fluid and tumor microenvironment.

Application

Angiogenin human has been used to treat chicken eggs to determine its activity by chorioallantoic membrane (CAM) analysis . It has also been used to determine the angiogenic activity of Candida albicans and Streptococcus pneumoniae cultures by chicken chorioallantoic membrane assay .

Biochem/physiol Actions

Angiogenin plays a role in several biological functions such as tumorigenesis, innate immunity, neuroprotection. It also plays a role in reproduction, regeneration of damaged tissues and neovascularization.
Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily.
Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily. Although the ribonucleolytic activity of angiogenin toward most RNase A substrates is lower than that of RNase A, this activity is essential to its angiogenic activity since inhibition of the angiogenin RNase activity will inhibit the angiogenic activity. High affinity receptors for angiogenin are expressed in cultured aortic smooth muscle cells and can be modulated by protamin, heparin and placental ribonuclease inhibitor.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Analysis Note

The activity of human angiogenin is tested in culture by measuring its ribonucleolytic activity for yeast tRNA.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Human angiogenin lacks specific antimicrobial activity
Avdeeva, Svetlana V, et al.
Current Microbiology, 53(6), 477-478 (2006)
J Badet
Pathologie-biologie, 47(4), 345-351 (1999-06-18)
Angiogenin is a heparin-binding 14 kDa plasma protein with angiogenic and ribonucleolytic activity. Although its structural features have been extensively studied, an understanding of its physiological role and of how its properties are expressed continues to elude researchers. This article
Evaluation of angiogenesis in diabetic lower limb wound healing using a natural medicine: A quantitative approach
Barui A, et al.
Wounds : a compendium of clinical research and practice, 6, 26-33 (2014)
D J Strydom
Cellular and molecular life sciences : CMLS, 54(8), 811-824 (1998-10-07)
The angiogenic and other biological functions of the angiogenins, members of the pancreatic RNase superfamily of proteins, are reviewed in the context of their primary and tertiary structures. The ribonucleolytic activity and interactions with the placental ribonuclease inhibitor have seen
Three decades of research on angiogenin: a review and perspective
Sheng J and Xu Z
Acta biochimica et biophysica Sinica, 48(5), 399-410 (2016)

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