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B3398

Sigma-Aldrich

Anti-Human IgG2−Biotin antibody, Mouse monoclonal

clone HP-6014, purified from hybridoma cell culture

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Synonym(s):
Monoclonal Anti-Human IgG2
NACRES:
NA.46

biological source

mouse

Quality Level

conjugate

biotin conjugate

antibody form

purified from hybridoma cell culture

antibody product type

secondary antibodies

clone

HP-6014, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

direct ELISA: 1:30,000

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

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This Item
B3773B3648B3523
species reactivity

human

species reactivity

rabbit, sheep, horse (IgG), goat, human

species reactivity

human

species reactivity

human

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

conjugate

biotin conjugate

conjugate

biotin conjugate

conjugate

biotin conjugate

conjugate

biotin conjugate

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

isotype

IgG1

isotype

IgG2a

isotype

IgG1

isotype

IgG1

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General description

Monoclonal Anti-Human IgG2 (mouse IgG1 isotype) is derived from the hybridoma (HP-60141 ) produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. IgG is the most abundant serum immunoglobulins of the immune system. IgG2 is a subtype of IgG. IgG is secreted by B cells and is found in blood and extracellular fluids.

Specificity

The antibody is specific for human IgG2 and is non-reactive with other IgG subclasses. This clone has been singled out as the most widely applicable IgG2 specific monoclonal antibody by the IUIS/WHO study.

Application

Monoclonal Anti-Human IgG2−Biotin antibody produced in mouse has been used in indirect enzyme linked immunosorbent assay (ELISA) and immunoblot.

Biochem/physiol Actions

IgG provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
Low IgG2 levels were found in patients with systemic lupus erythematosus (SLE) and juvenile diabetes melitus.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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