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C0742

Sigma-Aldrich

CKI-7 dihydrochloride

≥98% (HPLC), solid

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Synonym(s):
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride
Empirical Formula (Hill Notation):
C11H12ClN3O2S · 2HCl
CAS Number:
Molecular Weight:
358.67
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to light tan

solubility

H2O: >5 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12

InChI

1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H

InChI key

JUAVTXYOCISSSL-UHFFFAOYSA-N

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CKI-7 dihydrochloride ≥98% (HPLC), solid

C0742

CKI-7 dihydrochloride

Serotonin hydrochloride powder

H9523

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Sigma-Aldrich

SML0807

PreQ1 dihydrochloride

HA-1077 dihydrochloride solid, ≥98% (HPLC)

H139

HA-1077 dihydrochloride

assay

≥98% (HPLC)

assay

≥98%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

desiccated

solubility

H2O: >5 mg/mL

solubility

H2O: 17 mg/mL, 0.1 M HCl: 22 mg/mL, ethanol: 5.3 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

H2O: >10 mg/mL

Biochem/physiol Actions

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.

Caution

Material is hygroscopic

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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