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C0742

Sigma-Aldrich

CKI-7 dihydrochloride

≥98% (HPLC), solid, CK1 inhibitor

Synonym(s):

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H12ClN3O2S · 2HCl
CAS Number:
1177141-67-1
Molecular Weight:
358.67
MDL number:
MFCD00897689
UNSPSC Code:
12352200
PubChem Substance ID:
24724430
NACRES:
NA.77

Product Name

CKI-7 dihydrochloride, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to light tan

solubility

H2O: >5 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12

InChI

1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H

InChI key

JUAVTXYOCISSSL-UHFFFAOYSA-N

Biochem/physiol Actions

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1.
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.

Caution

Material is hygroscopic

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000405882
0000385438
0000335165
0000309193
0000309196

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Xueyuan Guo et al.
Chinese medical journal, 127(6), 1033-1038 (2014-03-14)
Neutrophil/lymphocyte ratio (NLR) has been proposed as a novel marker of systemic inflammation and oxidative stress. The objective of this study was to ascertain the relationship between levels of NLR and recurrence of lone atrial fibrillation (AF) after catheter ablation.
Hanna K Gaggin et al.
JACC. Heart failure, 2(1), 65-72 (2014-03-14)
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Martina Weber et al.
The American journal of clinical nutrition, 99(5), 1041-1051 (2014-03-14)
Early nutrition is recognized as a target for the effective prevention of childhood obesity. Protein intake was associated with more rapid weight gain during infancy-a known risk factor for later obesity. We tested whether the reduction of protein in infant
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Journal of clinical microbiology, 52(5), 1754-1757 (2014-03-14)
Qualitative and quantitative 16S rRNA gene-based real-time PCR and direct sequencing were applied for rapid detection and identification of bacterial DNA (bactDNA) in 356 ascites samples. bactDNA was detected in 35% of samples, with a mean of 3.24 log copies
Subodh Verma et al.
The lancet. Diabetes & endocrinology, 1(4), 317-328 (2014-03-14)
The choice between coronary artery bypass surgery (CABG) and percutaneous coronary intervention (PCI) for revascularisation in patients with diabetes and multivessel coronary artery disease, who account for 25% of revascularisation procedures, is much debated. We aimed to assess whether all-cause
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