C0867

Anti-CRTH2 (GRP44) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Chemoattractant Receptor-homologous Molecule expressed on TH2 Cells, Anti-Putative G-Protein Coupled Receptor 44
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD08064414
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 3

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~43 kDa by calculation
• species reactivity: rat, mouse, human
• technique(s): western blot: 1:500-1:1,000 using CRTH2-transfected Jurkat cells
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... GPR44(11251) ; mouse ... Gpr44(14764) ; rat ... Gpr44(309212)

Description

Immunogen

peptide corresponding to the human CRTH2 (GRP44) protein, near the C-terminus (amino acids 329-348).

Application

Anti-CRTH2 (GRP44) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:1,000 using CRTH2- transfected Jurkat cells.

Biochem/physiol Actions

CRTH2 (chemoattractant receptor-homologous molecule), is known as the putative G protein-coupled receptor (GP44), is expressed on T helper 2 (Th2) cells. It is also referred as DP2, DL1R and CD294. It′s a human protein and belongs to G protein-coupled leukocyte chemo attractant receptor family. It is not expressed on human amniocytes or myocytes. On activation of CRTH2, PGD(2) induces human osteoclast apoptosis and the apoptosis intrinsic pathway. CRTH2, CD4 and T cells all together may be involved in the pathogenesis of IgG4-related Lacrimal gland enlargement (LGE) causing Mikulicz′s disease (MD).

Physical form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable