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C1063

Sigma-Aldrich

Chorionic gonadotropin human

lyophilized powder, vial of ~2,500 IU

Synonym(s):
Choriogonin, HCG
CAS Number:
MDL number:
NACRES:
NA.32

biological source

human urine

Quality Level

sterility

sterile-filtered

form

lyophilized powder

mol wt

37.9 kDa

contains

mannitol

packaging

vial of ~2,500 IU

drug control

Home Office Schedule 4.2

impurities

HBsAg, HCV and HIV-1/HIV-2, tested negative

solubility

water: 10 mL/vial, clear, colorless

UniProt accession no.

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... CGA(1081)

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1 of 4

This Item
CG5CG10C8554
sterility

sterile-filtered

sterility

sterile-filtered

sterility

sterile-filtered

sterility

aseptically processed

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

drug control

Home Office Schedule 4.2

drug control

Home Office Schedule 4.2

drug control

Home Office Schedule 4.2

drug control

Home Office Schedule 4.2

solubility

water: 10 mL/vial, clear, colorless

solubility

water: 10 mL/vial, clear to slightly hazy, colorless

solubility

water: 10 mL/vial, clear to slightly hazy, colorless

solubility

H2O: 1 mL/vial, saline: 1 mL/vial

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

dry ice

General description

Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

Application

Chorionic gonadotropin human has been used in the biological validation of urinary testosterone (UTM) and urinary estradiol metabolites (UEM) EIA and superovulation.

Biochem/physiol Actions

Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.

Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.

Reconstitution

When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.1 M sodium phosphate buffer (pH approx. 7.2) and 100 mg/mL of mannitol.

Analysis Note

The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 2,500 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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