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C1603

Sigma-Aldrich

Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-CACH2, Anti-CACN2, Anti-CACNL1A1, Anti-CCHL1A1, Anti-CaV1.2, Anti-LQT8, Anti-TS, Anti-TS. LQT8
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat, mouse, rabbit

technique(s)

immunohistochemistry: suitable using Rat brain sections
western blot: 1:200 using Rat brain and rat heart membranes

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cacna1c(12288)

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This Item
C1728C1353C1478
antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

UniProt accession no.

Q13936

UniProt accession no.

Q99246

UniProt accession no.

P54282

UniProt accession no.

Q02294

technique(s)

immunohistochemistry: suitable using Rat brain sections, western blot: 1:200 using Rat brain and rat heart membranes

technique(s)

immunocytochemistry: 1:30-1:150, immunoprecipitation (IP): suitable, western blot (chemiluminescent): 1:100-1:200

technique(s)

immunohistochemistry: 1:100, western blot: 1:200

technique(s)

immunocytochemistry: suitable using rat brain sections, immunoprecipitation (IP): suitable, western blot: 1:100-1:200 using rat brain membranes

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General description

L-type of Voltage-gated Ca2+ Channels (L-type VGCC) is a high voltage-activated channel that exerts spatial and temporal control over cellular calcium concentrations and modulates function such as neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression and neuronal survival. Calcium dependent processes are important in synaptic modification and thus alterations in calcium channel function may be important for both modifying synaptic plasticity and also in age-related neurodegenerative diseases. Calcium channel antagonists are used as antiarrhythmics and in the treatment of hypertension and may even be neuroprotective in Parkinson′s Disease. Calcium Channel α1C subunit is a pore-forming subunit that together with β subunits generates the necessary signal for membrane targeting of class C L-type calcium channels.

Specificity

Anti-Voltage-gated Calcium Channel α1C subunit recognizes the α1C subunit by immunoblotting in rat brain and rat heart membranes. Reactivity has been confirmed for rat, mouse, rabbit and human.

Immunogen

synthetic peptide corresponding to amino acids 848 to 865 of rat α1C.

Application

Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit has been used in:
  • SDS-PAGE
  • western blotting
  • coimmunoprecipitation
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Rabbit polyclonal anti-Calcium Channel α1C subunit antibody is used to tag class C L-type calcium channel subunit α1C for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA, immunoblotting, and immunoprecipitation. It is used as a probe to determine the presence and roles of calcium channel subunit α1C in class C L-type voltage-gated Ca2+ channel subunit complexes.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells
Kato HK, et al.
The Journal of Physiology, 590(13), 3019-3034 (2012)
Calcium channel function and regulation in beta1-and beta2-adrenoceptor transgenic mice
Foerster K, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 369(5), 490-495 (2004)
Nina Daschil et al.
Pharmacology, 93(1-2), 24-31 (2014-01-18)
It is well established that reactive astrocytes express L-type calcium channels (LTCC), but their functional role is completely unknown. We have recently shown that reactive astrocytes highly express the CaV1.2 α1-subunit around β-amyloid (Aβ) plaques in an Alzheimer mouse model.
Jing Liu et al.
American journal of physiology. Cell physiology, 297(1), C152-C159 (2009-04-10)
Cardiomyocytes (CMs) are nonregenerative. Self-renewable pluripotent human embryonic stem cells (hESCs) can differentiate into CMs for cell-based therapies. We recently reported that Ca(2+) handling, crucial to excitation-contraction coupling of hESC-derived CMs (hESC-CMs), is functional but immature. Such immature properties as
A S Axelsson et al.
Nature communications, 8, 15652-15652 (2017-06-07)
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective

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