All Photos(3)




Monoclonal Anti-CNPase antibody produced in mouse

clone 11-5B, ascites fluid

Sign Into View Organizational & Contract Pricing

Anti-CNP1, Anti-HLD20
MDL number:

biological source


Quality Level



antibody form

ascites fluid

antibody product type

primary antibodies


11-5B, monoclonal


15 mM sodium azide

species reactivity

mouse, rat, bovine, canine, pig, human, rabbit, sheep

should not react with

guinea pig, chicken


immunohistochemistry: suitable using brain sections
indirect ELISA: suitable
microarray: suitable
western blot: 1:500 using fresh bovine brain extract



UniProt accession no.

shipped in

dry ice

storage temp.


target post-translational modification


Gene Information

human ... CNP(1267)
mouse ... Cnp(12799)
rat ... Cnp(25275)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item








antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

ascites fluid


11-5B, monoclonal


11-5B, monoclonal




HM-1, monoclonal

species reactivity

mouse, rat, bovine, canine, pig, human, rabbit, sheep

species reactivity

pig (pig origin but not guinea pig), sheep, rat, bovine, rabbit, canine, human, mouse

species reactivity

human, mouse, rat

species reactivity

mouse, rat


immunohistochemistry: suitable using brain sections, indirect ELISA: suitable, microarray: suitable, western blot: 1:500 using fresh bovine brain extract


immunoblotting: 5-10 μg/mL using whole rat brain extract


flow cytometry: 1:200-1:500, immunohistochemistry: 1:100-1:200, western blot: 1:500-1:1,000


immunohistochemistry (frozen sections): suitable, microarray: suitable, western blot: 1:500 using a fresh total rat brain extract or an enriched microtubule protein preparation

Still not finding the right product?  

Give our Product Selector Tool a try.

General description

CNPase (2′,3′-cyclic nucleotide 3′-phosphodiesterase, E.C.3.1.4. 37) is a unique enzyme. It is a constituent of cells that elaborate myelin in the central and peripheral nervous systems, i.e. oligodendrocytes and Schwann cells respectively, and is virtually absent in other cell types in the nervous system.
The enzyme isolated from mammalian brain is primarily a mixed dimer of approximately 94 kDa. The dimer consists of a varied proportion of CNP1 (46 kDa) and CNP2 (48 kDa) subunits in various species. The high levels of CNPase observed in oligodendrocytes and Schwann cells portend a vital role of this enzyme in the normal function of these cells. They are distinguished from nearly all other cells by their ability to synthesize and maintain vast amounts of multilamellar membrane, known as myelin. It seems very likely that CNPase is expressed at high levels in these particular cells to facilitate the elaboration and maintenance of myelin or to carry out functions imposed or afforded by the unique membrane structure of myelin. Since the enzyme is a myelin-associated enzyme, it is of considerable interest in the study of diseases and disorders in which myelin is affected, such as multiple sclerosis, subacute sclerosing panencephalitis, acquired immunodefi ciency with CNS involvement, peripheral neuropathies, etc. Another important use is the study of reinnervation of the neuromuscular junction and the identification of oligodendrocyte progenitor cells, very early in postnatal development.


Monoclonal Anti-CNPase reacts specifically with CNPase in ELISA, immunoblotting and immunohistochemical staining of brain sections. In an immunoblotting assay, the antibody localizes both CNP1 (46kD) and CNP2 (48kD) bands of the enzyme and recognizes whole brain CNPase of human, bovine, mouse, rat, rabbit, dog, sheep and pig but not guinea pig or chicken. Immunohistochemical staining performed on paraffin, cryostat, or vibratome sections of rat brain, reveals a selective staining of oligodendrocytes in the grey and white matter. Nerve cells and axons are not stained and astroglial cells do not appear to be labeled.
The antibody reacts specifically with CNPase in oligodendrocytes and Schwann cells. Recognizes whole brain CNPase. Nerve cells, axons, and astroglial cells do not appear to be labeled. Using immunoblotting techniques, the antibody localizes both CNP1 and CNP2 bands of the enzyme.


human 2′,3′-cyclic nucleotide-3′-phosphodiesterase (E.C., CNPase).


Monoclonal Anti-CNPase may be used for the localization of CNPase using various immunochemical assays such as ELISA, immunoblot, dot blot and immunocytochemistry. It has also been used in immunohistochemistry.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).


Product Number
Pack Size/Quantity

Additional examples:





enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia
Takao K, et al.
Neuropsychopharmacology, 38(8), 1409-1409 (2013)
Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury
Marignier R, et al.
Brain, 133(9), 2578-2591 (2010)
Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons
Wuthrich C, et al.
Annals of Neurology, 65(6), 742-748 (2009)
Natalia D Andersen et al.
Scientific reports, 6, 31781-31781 (2016-08-24)
We herein developed a protocol for the rapid procurement of adult nerve-derived Schwann cells (SCs) that was optimized to implement an immediate enzymatic dissociation of fresh nerve tissue while maintaining high cell viability, improving yields and minimizing fibroblast and myelin
Raffaela Cipriani et al.
Journal of neuroinflammation, 14(1), 147-147 (2017-07-26)
FTY720 (fingolimod, Gilenya™) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts several effects in the central nervous system (CNS), ranging from neuroprotection to reduction of

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service