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C7806

Sigma-Aldrich

Collagen from bovine nasal septum

Bornstein and Traub Type II, powder

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Synonym(s):
Collagen from bovine
CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

bovine nasal septum

Quality Level

form

powder

technique(s)

ELISA: suitable

solubility

aqueous acid: soluble

UniProt accession no.

storage temp.

2-8°C

Gene Information

bovine ... COL2A1(407142)

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This Item
C9879C1188C9791
vibrant-m

C7806

Collagen from bovine nasal septum

vibrant-m

C9791

Collagen from calf skin

biological source

bovine nasal septum

biological source

bovine Achilles tendon

biological source

bovine cartilage (tracheal)

biological source

bovine (calf) skin

form

powder

form

powder

form

powder

form

solid

solubility

aqueous acid: soluble

solubility

-

solubility

aqueous acid: soluble

solubility

0.1 M acetic acid: 1 mg/mL (Allow to stir at room temperature 1-3 hours until dissolved.)

UniProt accession no.

P02459

UniProt accession no.

P02459

UniProt accession no.

P02459

UniProt accession no.

P02453

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Collagen is a fibrous protein, found in connective tissues, hard tissues, bone, dentin, cementum and also the mineralizing cartilage of the epiphyseal growth plate.
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen from bovine nasal septum has been used to coat the plates to estimate the levels of serum anti-cII IgG by enzyme-linked immunosorbent assay (ELISA). It has also been used as a component in the emulsified agent to induce arthritis in rats.
Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type 2. Collagen-type 2 has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.

Biochem/physiol Actions

Collagen is the structural constituent of the dermis, which provides strength and support to the human skin. Variations in collagen participates in the aging process.

Preparation Note

An acid soluble collagen soluble in dilute acetic acid at pH 3.0 (5 mg/ml), yielding an opalescent, colorless solution.
Collagen Type II is a triple helix composed of three α1(II) strands.
Prepared by a modification of the pepsin extraction procedure of Niyibizi, et al., J. Biol. Chem., 259, 14170 (1984).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats
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Aging and the skin
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Aspects of collagen mineralization in hard tissue formation
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International Review of Cytology, 242, 121-156 (2005)
Rui Liu et al.
Therapeutic advances in chronic disease, 12, 2040622321991705-2040622321991705 (2021-05-18)
Evidence has demonstrated that non-coding RNAs (ncRNAs) could be delivered efficiently to recipient cells using exosomes as a carrier. Additionally, long ncRNA nuclear enriched abundant transcript 1 (NEAT1) is emerging as a vital regulatory molecule in the progression of rheumatoid
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
Korganow AS, et al.
Immunity, 10(4), 451-461 (1999)

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