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Diphtheria Toxin from Corynebacterium diphtheriae

lyophilized powder, Product is in unnicked form

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lyophilized powder

storage temp.


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storage temp.


storage temp.


storage temp.


storage temp.


Quality Level


Quality Level


Quality Level


Quality Level



Diphtheria Toxin from Corynebacterium diphtheriae has been:
  • used for microglia depletion to study post-traumatic stress disorder in mice
  • intraperitoneally injected in transgenic mice to select the hybrids after fusion of transplanted hematopoietic stem and progenitor cells (HSPCs) during ablation
  • used to study its effect on eosinophil lineage-committed progenitors in an eosinophil-deficient strain of mice (iPHIL)

Diphtheria toxin may be used as a toxin element in the construction of immunotoxin for cell specific cytotoxicity. The translocation domain of bacterial toxins with natural endosome escape mechanism has been used in the development of efficient nonviral vectors for applications in gene therapy.

Biochem/physiol Actions

Diphtheria toxin is a bacterial toxin produced from Corynebacterium diphtheriae. It contains three domains that have intracellular actions. The domains are involved in the intoxication of the cell, cell-surface binding and internalization into endosomes, translocating into the cytosol across the endosome membrane and inhibiting cellular protein synthesis. Diphtheria toxin is useful in constructing biotechnological tools and therapeutics. It inhibits protein synthesis by catalyzing adenosine diphosphate (ADP)-ribosylation of the target protein in eukaryotes.

Physical form

Lyophilized powder containing Tris and EDTA.


Each vial, when reconstituted to 0.5 mL with sterile distilled water, contains ~1 mg of diphtheria toxin in 0.01 M Tris and 0.001 M Na2EDTA, pH 7.5.


Skull and crossbones

Signal Word


Hazard Statements

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Biology and molecular epidemiology of diphtheria toxin and the tox gene
The Journal of Infectious Diseases, 181 (2000)
Diphtheria toxin
The Comprehensive Sourcebook of Bacterial Protein Toxins (2015)
S M Yellon et al.
Biology of reproduction, 100(5), 1386-1394 (2019-01-11)
To test the hypothesis that macrophages are essential for remodeling the cervix in preparation for birth, pregnant homozygous CD11b-dtr mice were injected with diphtheria toxin (DT) on days 14 and 16 postbreeding. On day 15 postbreeding, macrophages (F4/80+) were depleted
Benjamin J Vakoc et al.
Nature medicine, 15(10), 1219-1223 (2009-09-15)
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous contrast agents that enable multiphoton microscopy, however, limit the ability
Allah Nawaz et al.
Nature communications, 8(1), 286-286 (2017-08-19)
Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or anti-inflammatory cytokines. Here, we show that M2-like macrophages in adipose tissue regulate systemic glucose homeostasis by inhibiting

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