Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

D8040

Sigma-Aldrich

(±)-trans-U-50488 methanesulfonate salt

Synonym(s):

trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate salt, U-50488H

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C19H26Cl2N2O · CH4O3S
Molecular Weight:
465.43
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

solubility

H2O: 50 mg/mL

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3

InChI

1S/C19H26Cl2N2O.CH4O3S/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;1-5(2,3)4/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H3,(H,2,3,4)/t17-,18-;/m1./s1

InChI key

OJPHNZCUXUUVKU-JAXOOIEVSA-N

Gene Information

human ... OPRK1(4986)

Application

(±)-trans-U-50488 methanesulfonate salt has been used as a control agonist for κ-opioid receptor.

Biochem/physiol Actions

Selective κ-opioid receptor agonist. (±)-trans-U-50488 methanesulfonate salt is known to induce diuresis. U-50488H is found to prevent morphine tolerance when administered along with it.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
Chajra H, et al.
International Journal of Cosmetic Science, 37(4), 386-394 (2015)
Guang-Jie Gao et al.
Evidence-based complementary and alternative medicine : eCAM, 2022, 2868135-2868135 (2022-08-30)
Acute lung injury (ALI) is one of the common and severe complications of cardiopulmonary bypass (CPB), which is the primary cause of death in intensive care units. Nevertheless, there is a lack of effective treatment for ALI secondary to CPB.
X C Yu et al.
Journal of molecular and cellular cardiology, 31(10), 1809-1819 (1999-10-20)
During myocardial ischaemia the beta-adrenoceptor is activated, which contributes, at least partly, to cardiac arrhythmias via inducing [Ca2+]i oscillations. Since beta-adrenoceptor is negatively modulated by the kappa-opioid receptor in the heart, the present study attempted to determine if kappa-opioid receptor
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain
Basile AS, et al.
Journal of Pharmacology and Experimental Therapeutics, 321(3), 1208-1225 (2007)
Moriah L Jacobson et al.
Psychopharmacology, 237(12), 3715-3728 (2020-09-08)
Major depressive disorder is a leading cause of disability worldwide and is likely precipitated by chronic stress. Although many antidepressants are currently available, these drugs require weeks to months of daily administration before reduction of symptoms occurs and many patients

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service